Expression of macrophage colony stimulating factor in brains of PDAPPV717I transgenic mice

Jian min Zhang, Qing li Kong, Hong Wang, Chuan Qin, Wei He

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To identify the expression and distribution of macrophage colony stimulating factor (M-CSF) in brains of PDAPPV717I transgenic mice. METHODS: We detected the expression and distribution of M-CSF mRNA in brains of PDAPPV717I transgenic mice by using hybridization in situ and immunohistochemical staining. RESULTS: Expression of M-CSF mRNA was significantly higher in brains of PDAPPV717I transgenic mice than that in non-transgenic mice, and M-CSF mRNA in brain was mainly produced by reactive astrocytes. CONCLUSION: The results indicate that astrocytes play an important role in the onset/development of neuropathology of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)62-65
Number of pages4
JournalZhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
Volume26
Issue number1
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Expression of macrophage colony stimulating factor in brains of PDAPPV717I transgenic mice'. Together they form a unique fingerprint.

  • Cite this