Abstract
OBJECTIVE: To identify the expression and distribution of macrophage colony stimulating factor (M-CSF) in brains of PDAPPV717I transgenic mice. METHODS: We detected the expression and distribution of M-CSF mRNA in brains of PDAPPV717I transgenic mice by using hybridization in situ and immunohistochemical staining. RESULTS: Expression of M-CSF mRNA was significantly higher in brains of PDAPPV717I transgenic mice than that in non-transgenic mice, and M-CSF mRNA in brain was mainly produced by reactive astrocytes. CONCLUSION: The results indicate that astrocytes play an important role in the onset/development of neuropathology of Alzheimer's disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 62-65 |
| Number of pages | 4 |
| Journal | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. |
| Volume | 26 |
| Issue number | 1 |
| State | Published - Feb 2004 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Medicine