Natural killer (NK) activity is mediated by large granulated lymphocytes (LGL). Recently, the relationship of NK cells to mast cells and basophils has been suggested. We therefore examined 3 distinct interleukin 2-dependent cloned cell lines capable of mediating NK lysis. Virtually all the cells of each line contained membrane-bound granules. Interestingly, ultrastructural studies demonstrated that the granules in each cell line were morphologically distinct and thus heterogeneous. All 3 cloned, granulated NK cell lines were found to variably express low numbers (≤ 1.3 x 104) of low affinity plasma membrane IgE receptors (FcεR). In contrast to mast cells and basophils, however, none were found to express high numbers of high affinity FcεR. In addition, none of the 3 NK cell lines were found to contain histaminase-sensitive histamine. Our results suggest that NK cells are not related to mast cells or basophils.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Immunology|
|State||Published - Sep 20 1984|
ASJC Scopus subject areas
- Immunology and Allergy