Expression of D2 dopamine receptor mRNA in the arterial chemoreceptor afferent pathway

Maria F. Czyzyk-Krzeska; Edward E. Lawson; David E. Millhorn

doi:10.1016/0165-1838(92)90124-Y

Expression of D₂ dopamine receptor mRNA in the arterial chemoreceptor afferent pathway

Maria F. Czyzyk-Krzeska, Edward E. Lawson, David E. Millhorn

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Dopamine is a major neurotransmitter in the arterial chemoreceptor pathway. In the present study we wished to determine if messenger RNAs for dopamine D₁ and D₂ receptor are expressed in carotid body (type I cells), in sensory neurons of the petrosal ganglion which innervate the carotid body and in sympathetic neurons of the superior cervical ganglion. We failed to detect D₁ receptor mRNA in any of these tissues. However, we found that D₂ receptor mRNA was expressed by dopaminergic carotid body type I cells. D₂ receptor mRNA was also found in petrosal ganglion neurons that innervated the carotid sinus and carotid body. In addition, a large number of sympathetic postganglionic neurons in the superior cervical ganglion expressed D₂ receptor mRNA.

Original language	English (US)
Pages (from-to)	31-39
Number of pages	9
Journal	Journal of the Autonomic Nervous System
Volume	41
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-1838(92)90124-Y
State	Published - Nov 1992
Externally published	Yes

Keywords

Carotid body
Dopamine
Dopamine receptor
Petrosal ganglion
Superior cervical ganglion
mRNA

ASJC Scopus subject areas

General Neuroscience
Physiology
Clinical Neurology

Access to Document

10.1016/0165-1838(92)90124-Y

Cite this

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title = "Expression of D2 dopamine receptor mRNA in the arterial chemoreceptor afferent pathway",

abstract = "Dopamine is a major neurotransmitter in the arterial chemoreceptor pathway. In the present study we wished to determine if messenger RNAs for dopamine D1 and D2 receptor are expressed in carotid body (type I cells), in sensory neurons of the petrosal ganglion which innervate the carotid body and in sympathetic neurons of the superior cervical ganglion. We failed to detect D1 receptor mRNA in any of these tissues. However, we found that D2 receptor mRNA was expressed by dopaminergic carotid body type I cells. D2 receptor mRNA was also found in petrosal ganglion neurons that innervated the carotid sinus and carotid body. In addition, a large number of sympathetic postganglionic neurons in the superior cervical ganglion expressed D2 receptor mRNA.",

keywords = "Carotid body, Dopamine, Dopamine receptor, Petrosal ganglion, Superior cervical ganglion, mRNA",

author = "Czyzyk-Krzeska, {Maria F.} and Lawson, {Edward E.} and Millhorn, {David E.}",

note = "Funding Information: The authors thank Mrs. Luisa Brighton for her excellent technical assistance. This study was supported by National Institutes of Health grants HL 33831, HL 34919, and HD 28948, a grant from the American Heart Association (91-009960), and a research grant from the American Lung Association (National). D.E.M. is Carrer Investigator of the American Lung Association.",

year = "1992",

month = nov,

doi = "10.1016/0165-1838(92)90124-Y",

language = "English (US)",

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pages = "31--39",

journal = "Journal of the Autonomic Nervous System",

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T1 - Expression of D2 dopamine receptor mRNA in the arterial chemoreceptor afferent pathway

AU - Czyzyk-Krzeska, Maria F.

AU - Lawson, Edward E.

AU - Millhorn, David E.

N1 - Funding Information: The authors thank Mrs. Luisa Brighton for her excellent technical assistance. This study was supported by National Institutes of Health grants HL 33831, HL 34919, and HD 28948, a grant from the American Heart Association (91-009960), and a research grant from the American Lung Association (National). D.E.M. is Carrer Investigator of the American Lung Association.

PY - 1992/11

Y1 - 1992/11

N2 - Dopamine is a major neurotransmitter in the arterial chemoreceptor pathway. In the present study we wished to determine if messenger RNAs for dopamine D1 and D2 receptor are expressed in carotid body (type I cells), in sensory neurons of the petrosal ganglion which innervate the carotid body and in sympathetic neurons of the superior cervical ganglion. We failed to detect D1 receptor mRNA in any of these tissues. However, we found that D2 receptor mRNA was expressed by dopaminergic carotid body type I cells. D2 receptor mRNA was also found in petrosal ganglion neurons that innervated the carotid sinus and carotid body. In addition, a large number of sympathetic postganglionic neurons in the superior cervical ganglion expressed D2 receptor mRNA.

AB - Dopamine is a major neurotransmitter in the arterial chemoreceptor pathway. In the present study we wished to determine if messenger RNAs for dopamine D1 and D2 receptor are expressed in carotid body (type I cells), in sensory neurons of the petrosal ganglion which innervate the carotid body and in sympathetic neurons of the superior cervical ganglion. We failed to detect D1 receptor mRNA in any of these tissues. However, we found that D2 receptor mRNA was expressed by dopaminergic carotid body type I cells. D2 receptor mRNA was also found in petrosal ganglion neurons that innervated the carotid sinus and carotid body. In addition, a large number of sympathetic postganglionic neurons in the superior cervical ganglion expressed D2 receptor mRNA.

KW - Carotid body

KW - Dopamine

KW - Dopamine receptor

KW - Petrosal ganglion

KW - Superior cervical ganglion

KW - mRNA

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