Expression of cystatin C in human esophageal cancer

Qinghong Zeng, Yonggang Zhao, Yuxian Yang, Guiyu Zheng, Gefei Wang, Peng Zhang, Youhong Cui, Shaobo Su, Kangsheng Li

Research output: Contribution to journalArticle

Abstract

Aims and background. Cystatin C is a member of the cysteine protease inhibitors and its function is to decrease protease activity. A recent study showed that it was aberrantly expressed in many malignant tumors in association with tumor invasion and metastasis. We attempted to detect its expression in esophageal cancer tissues and adjacent reparative normal tissues. Methods and design. Samples of cancers and non-cancerous esophageal tissues were obtained as matched pairs from 30 surgery patients with esophageal cancer and paraffin embedded. The expression of cystatin C in tissues was investigated by immunohistochemistry. Fisher's exact test was used to analyze the relationship between esophageal cancer tissues and adjacent normal tissues. Furthermore, mRNA was extracted, and reverse transcriptase polymerase chain reaction was performed. Results. The intensity of cystatin C immunostaining in tumor tissues was increased compared to that of adjacent normal tissues.mRNA expression of the cystatin C gene was greater in esophageal cancer than in normal tissues (P <0.05). Conclusions. Our results indicate that cystatin C may play an important role in the pathogenesis and metastasis of esophageal cancer.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalTumori
Volume97
Issue number2
DOIs
StatePublished - 2011

Keywords

  • Cystatin C
  • Esophageal cancer
  • Immunohistochemistry
  • Reverse transcriptase-polymerase chain reaction

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Zeng, Q., Zhao, Y., Yang, Y., Zheng, G., Wang, G., Zhang, P., Cui, Y., Su, S., & Li, K. (2011). Expression of cystatin C in human esophageal cancer. Tumori, 97(2), 203-210. https://doi.org/10.1177/030089161109700212