Expression of cell cycle related proteins in a rapidly growing uveal malignant melanoma

Shigeru Honda, Tatsuya Hirai, James T. Handa, Tomoko Okuno, Isao Saito

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To report the clinical and immunohistochemical findings of a rapidly growing uveal melanoma. Methods: A 71-year-old Japanese woman was diagnosed with a juxtapapillary uveal melanoma by clinical examination. The tumor grew rapidly with a 31.5-day doubling time. An enucleation was performed, and immunohistochemical examination for cell cycle proteins was performed in addition to routine histopathologic examination. Results: The melanoma cells were classified as spindle B-cells. The tumor cells were positive for HMB-45 protein, but negative for S-100 protein. The tumor showed immunohistochemical staining for p16 and Bcl-2, although p53 was not detected, Immunoreactivity for pRb was found in normal retinal and choroidal cells but not in the tumor cells. Conclusion: This report describes a unique case of rapidly growing uveal melanoma, which showed low histopathologic grade while the cell cycle protein immunohistochemical profile suggests a more aggressive phenotype. The evaluation of cell cycle proteins may be useful adjunctive method to enhance the understanding of uveal melanoma growth patterns.

Original languageEnglish (US)
Pages (from-to)646-649
Number of pages4
JournalRetina
Volume24
Issue number4
DOIs
StatePublished - Aug 1 2004

Keywords

  • Immunohistochemistry
  • Rapid growth
  • Uveal melanoma
  • p53
  • pRb

ASJC Scopus subject areas

  • Ophthalmology

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