Abstract
Purpose: To report the clinical and immunohistochemical findings of a rapidly growing uveal melanoma. Methods: A 71-year-old Japanese woman was diagnosed with a juxtapapillary uveal melanoma by clinical examination. The tumor grew rapidly with a 31.5-day doubling time. An enucleation was performed, and immunohistochemical examination for cell cycle proteins was performed in addition to routine histopathologic examination. Results: The melanoma cells were classified as spindle B-cells. The tumor cells were positive for HMB-45 protein, but negative for S-100 protein. The tumor showed immunohistochemical staining for p16 and Bcl-2, although p53 was not detected, Immunoreactivity for pRb was found in normal retinal and choroidal cells but not in the tumor cells. Conclusion: This report describes a unique case of rapidly growing uveal melanoma, which showed low histopathologic grade while the cell cycle protein immunohistochemical profile suggests a more aggressive phenotype. The evaluation of cell cycle proteins may be useful adjunctive method to enhance the understanding of uveal melanoma growth patterns.
Original language | English (US) |
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Pages (from-to) | 646-649 |
Number of pages | 4 |
Journal | Retina |
Volume | 24 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2004 |
Keywords
- Immunohistochemistry
- Rapid growth
- Uveal melanoma
- p53
- pRb
ASJC Scopus subject areas
- Ophthalmology