Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression

Vera J M Wielenga, Karl Heinz Heider, G. Johan A Offerhaus, Günther R. Adolf, Frank M. Van Den Berg, Helmut Ponta, Peter Herrlich, Steven T. Pals

Research output: Contribution to journalArticle

Abstract

Specific CD44 variant glycoproteins are overexpressed at particular stages of colorectal tumor progression. Some variants of the CD44 glycoprotein without exon v6 sequences appear at the earliest stage of tumorigenesis, i.e., in early adenomas. Expression of variants containing exon v6 sequences is largely restricted to the advanced stages of tumor development and in addition is more prevalent and intense in metastatic (Dukes C/D) than in nonmetastatic (Dukes A/B) carcinomas. The observation that CD44 variants containing a protein domain of CD44 that confers full metastatic potential to rat carcinoma and sarcoma cell lines is increasingly expressed during colorectal tumor progression indicates that this domain may have an important role in tumor progression and metastasis in humans. Information on v6 expression, which can be obtained by routine immunohistochemistry, may prove of important prognostic value, particularly in carcinomas (Dukes A and B) that have not yet given rise to detectable metastases.

Original languageEnglish (US)
Pages (from-to)4754-4756
Number of pages3
JournalCancer Research
Volume53
Issue number20
StatePublished - Oct 15 1993
Externally publishedYes

Fingerprint

Colorectal Neoplasms
Carcinoma
Exons
Glycoproteins
Neoplasm Metastasis
Neoplasms
Proteins
Sarcoma
Adenoma
Carcinogenesis
Immunohistochemistry
Cell Line
Protein Domains

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Wielenga, V. J. M., Heider, K. H., Offerhaus, G. J. A., Adolf, G. R., Van Den Berg, F. M., Ponta, H., ... Pals, S. T. (1993). Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. Cancer Research, 53(20), 4754-4756.

Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. / Wielenga, Vera J M; Heider, Karl Heinz; Offerhaus, G. Johan A; Adolf, Günther R.; Van Den Berg, Frank M.; Ponta, Helmut; Herrlich, Peter; Pals, Steven T.

In: Cancer Research, Vol. 53, No. 20, 15.10.1993, p. 4754-4756.

Research output: Contribution to journalArticle

Wielenga, VJM, Heider, KH, Offerhaus, GJA, Adolf, GR, Van Den Berg, FM, Ponta, H, Herrlich, P & Pals, ST 1993, 'Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression', Cancer Research, vol. 53, no. 20, pp. 4754-4756.
Wielenga VJM, Heider KH, Offerhaus GJA, Adolf GR, Van Den Berg FM, Ponta H et al. Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. Cancer Research. 1993 Oct 15;53(20):4754-4756.
Wielenga, Vera J M ; Heider, Karl Heinz ; Offerhaus, G. Johan A ; Adolf, Günther R. ; Van Den Berg, Frank M. ; Ponta, Helmut ; Herrlich, Peter ; Pals, Steven T. / Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. In: Cancer Research. 1993 ; Vol. 53, No. 20. pp. 4754-4756.
@article{621623768a56439aa3ab139b89f3e5ef,
title = "Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression",
abstract = "Specific CD44 variant glycoproteins are overexpressed at particular stages of colorectal tumor progression. Some variants of the CD44 glycoprotein without exon v6 sequences appear at the earliest stage of tumorigenesis, i.e., in early adenomas. Expression of variants containing exon v6 sequences is largely restricted to the advanced stages of tumor development and in addition is more prevalent and intense in metastatic (Dukes C/D) than in nonmetastatic (Dukes A/B) carcinomas. The observation that CD44 variants containing a protein domain of CD44 that confers full metastatic potential to rat carcinoma and sarcoma cell lines is increasingly expressed during colorectal tumor progression indicates that this domain may have an important role in tumor progression and metastasis in humans. Information on v6 expression, which can be obtained by routine immunohistochemistry, may prove of important prognostic value, particularly in carcinomas (Dukes A and B) that have not yet given rise to detectable metastases.",
author = "Wielenga, {Vera J M} and Heider, {Karl Heinz} and Offerhaus, {G. Johan A} and Adolf, {G{\"u}nther R.} and {Van Den Berg}, {Frank M.} and Helmut Ponta and Peter Herrlich and Pals, {Steven T.}",
year = "1993",
month = "10",
day = "15",
language = "English (US)",
volume = "53",
pages = "4754--4756",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "20",

}

TY - JOUR

T1 - Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression

AU - Wielenga, Vera J M

AU - Heider, Karl Heinz

AU - Offerhaus, G. Johan A

AU - Adolf, Günther R.

AU - Van Den Berg, Frank M.

AU - Ponta, Helmut

AU - Herrlich, Peter

AU - Pals, Steven T.

PY - 1993/10/15

Y1 - 1993/10/15

N2 - Specific CD44 variant glycoproteins are overexpressed at particular stages of colorectal tumor progression. Some variants of the CD44 glycoprotein without exon v6 sequences appear at the earliest stage of tumorigenesis, i.e., in early adenomas. Expression of variants containing exon v6 sequences is largely restricted to the advanced stages of tumor development and in addition is more prevalent and intense in metastatic (Dukes C/D) than in nonmetastatic (Dukes A/B) carcinomas. The observation that CD44 variants containing a protein domain of CD44 that confers full metastatic potential to rat carcinoma and sarcoma cell lines is increasingly expressed during colorectal tumor progression indicates that this domain may have an important role in tumor progression and metastasis in humans. Information on v6 expression, which can be obtained by routine immunohistochemistry, may prove of important prognostic value, particularly in carcinomas (Dukes A and B) that have not yet given rise to detectable metastases.

AB - Specific CD44 variant glycoproteins are overexpressed at particular stages of colorectal tumor progression. Some variants of the CD44 glycoprotein without exon v6 sequences appear at the earliest stage of tumorigenesis, i.e., in early adenomas. Expression of variants containing exon v6 sequences is largely restricted to the advanced stages of tumor development and in addition is more prevalent and intense in metastatic (Dukes C/D) than in nonmetastatic (Dukes A/B) carcinomas. The observation that CD44 variants containing a protein domain of CD44 that confers full metastatic potential to rat carcinoma and sarcoma cell lines is increasingly expressed during colorectal tumor progression indicates that this domain may have an important role in tumor progression and metastasis in humans. Information on v6 expression, which can be obtained by routine immunohistochemistry, may prove of important prognostic value, particularly in carcinomas (Dukes A and B) that have not yet given rise to detectable metastases.

UR - http://www.scopus.com/inward/record.url?scp=0027517773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027517773&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 4754

EP - 4756

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 20

ER -