Expression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH- 3T3 cell growth

Masahiro Isogai, Maria V. Chiantore, Moneera Haque, Giorgio Scita, Luigi M. De Luca

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously reported an unexpected relationship between retinoic acid-induced inhibition of cell growth and the ability of various cell lines to metabolize the retinoid. Here, we report that stable expression of the truncated retinoic acid receptor RARα403, transduced in NIH-3T3 cells by a retrovital vector, rendered the cells resistant to retinoic acid for growth inhibition and reduced their ability to metabolize the retinoid at the fame time as it blunted the induction of the target gene transglutaminase II. The data suggest that retinoic acid receptors mediate the growth inhibitory action of retinoic acid as well as its metabolism and the induction of transglutaminase II.

Original languageEnglish (US)
Pages (from-to)4460-4464
Number of pages5
JournalCancer Research
Volume57
Issue number20
StatePublished - Oct 15 1997
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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