Expression levels of protein kinase C-α in non-small-cell lung cancer

Michael Lahn; Chen Su; Shuyu Li; Marcio Chedid; Kimberly R. Hanna; Jeremy R. Graff; George E. Sandusky; Doreen Ma; Clet Niyikiza; Karen L. Sundell; William J. John; Thomas J. Giordano; David G. Beer; Blake M. Paterson; Eric Wen Su; Thomas F. Bumól

doi:10.3816/CLC.2004.n.032

Expression levels of protein kinase C-α in non-small-cell lung cancer

Michael Lahn, Chen Su, Shuyu Li, Marcio Chedid, Kimberly R. Hanna, Jeremy R. Graff, George E. Sandusky, Doreen Ma, Clet Niyikiza, Karen L. Sundell, William J. John, Thomas J. Giordano, David G. Beer, Blake M. Paterson, Eric Wen Su, Thomas F. Bumól

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Current treatments of non - small-cell lung cancer (NSCLC) are inadequate and new therapies are being developed that target specific cellular signaling proteins associated with tumor growth. One potential target is protein kinase C (PKC) - α, a signaling molecule with an important role in cell regulation and proliferation. The present study examines the expression levels of PKC-α in NSCLC to better understand the distribution of PKC-α in NSCLC. We analyzed tumor specimens from an independent tumor tissue bank to determine PKC-α protein and messenger RNA gene expression in NSCLC. In addition, we used publicly available gene expression array data to further understand PKC-α-associated gene expression profiles in NSCLC. We found that PKC-α is highly expressed in ≤ 20% of patients with NSCLC. We also found that PKC-α was preferentially expressed in adenocarcinoma compared with squamous cell carcinoma of the lung.

Original language	English (US)
Pages (from-to)	184-189
Number of pages	6
Journal	Clinical lung cancer
Volume	6
Issue number	3
DOIs	https://doi.org/10.3816/CLC.2004.n.032
State	Published - Nov 2004
Externally published	Yes

Keywords

Adenocarcinoma
Aprinocarsen
Gene expression array
Squamous cell carcinoma

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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10.3816/CLC.2004.n.032

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title = "Expression levels of protein kinase C-α in non-small-cell lung cancer",

abstract = "Current treatments of non - small-cell lung cancer (NSCLC) are inadequate and new therapies are being developed that target specific cellular signaling proteins associated with tumor growth. One potential target is protein kinase C (PKC) - α, a signaling molecule with an important role in cell regulation and proliferation. The present study examines the expression levels of PKC-α in NSCLC to better understand the distribution of PKC-α in NSCLC. We analyzed tumor specimens from an independent tumor tissue bank to determine PKC-α protein and messenger RNA gene expression in NSCLC. In addition, we used publicly available gene expression array data to further understand PKC-α-associated gene expression profiles in NSCLC. We found that PKC-α is highly expressed in ≤ 20% of patients with NSCLC. We also found that PKC-α was preferentially expressed in adenocarcinoma compared with squamous cell carcinoma of the lung.",

keywords = "Adenocarcinoma, Aprinocarsen, Gene expression array, Squamous cell carcinoma",

author = "Michael Lahn and Chen Su and Shuyu Li and Marcio Chedid and Hanna, {Kimberly R.} and Graff, {Jeremy R.} and Sandusky, {George E.} and Doreen Ma and Clet Niyikiza and Sundell, {Karen L.} and John, {William J.} and Giordano, {Thomas J.} and Beer, {David G.} and Paterson, {Blake M.} and Su, {Eric Wen} and Bum{\'o}l, {Thomas F.}",

year = "2004",

month = nov,

doi = "10.3816/CLC.2004.n.032",

language = "English (US)",

volume = "6",

pages = "184--189",

journal = "Clinical lung cancer",

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AU - Lahn, Michael

AU - Su, Chen

AU - Li, Shuyu

AU - Chedid, Marcio

AU - Hanna, Kimberly R.

AU - Graff, Jeremy R.

AU - Sandusky, George E.

AU - Ma, Doreen

AU - Niyikiza, Clet

AU - Sundell, Karen L.

AU - John, William J.

AU - Giordano, Thomas J.

AU - Beer, David G.

AU - Paterson, Blake M.

AU - Su, Eric Wen

AU - Bumól, Thomas F.

PY - 2004/11

Y1 - 2004/11

N2 - Current treatments of non - small-cell lung cancer (NSCLC) are inadequate and new therapies are being developed that target specific cellular signaling proteins associated with tumor growth. One potential target is protein kinase C (PKC) - α, a signaling molecule with an important role in cell regulation and proliferation. The present study examines the expression levels of PKC-α in NSCLC to better understand the distribution of PKC-α in NSCLC. We analyzed tumor specimens from an independent tumor tissue bank to determine PKC-α protein and messenger RNA gene expression in NSCLC. In addition, we used publicly available gene expression array data to further understand PKC-α-associated gene expression profiles in NSCLC. We found that PKC-α is highly expressed in ≤ 20% of patients with NSCLC. We also found that PKC-α was preferentially expressed in adenocarcinoma compared with squamous cell carcinoma of the lung.

AB - Current treatments of non - small-cell lung cancer (NSCLC) are inadequate and new therapies are being developed that target specific cellular signaling proteins associated with tumor growth. One potential target is protein kinase C (PKC) - α, a signaling molecule with an important role in cell regulation and proliferation. The present study examines the expression levels of PKC-α in NSCLC to better understand the distribution of PKC-α in NSCLC. We analyzed tumor specimens from an independent tumor tissue bank to determine PKC-α protein and messenger RNA gene expression in NSCLC. In addition, we used publicly available gene expression array data to further understand PKC-α-associated gene expression profiles in NSCLC. We found that PKC-α is highly expressed in ≤ 20% of patients with NSCLC. We also found that PKC-α was preferentially expressed in adenocarcinoma compared with squamous cell carcinoma of the lung.

KW - Adenocarcinoma

KW - Aprinocarsen

KW - Gene expression array

KW - Squamous cell carcinoma

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Expression levels of protein kinase C-α in non-small-cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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