Expression kinetics of hepatic progenitor markers in cellular models of human liver development recapitulating hepatocyte and biliary cell fate commitment

Pooja Chaudhari, Lipeng Tian, Abhijeet Deshmukh, Yoon Young Jang

Research output: Contribution to journalArticlepeer-review

Abstract

Due to the limitations of research using human embryos and the lack of a biological model of human liver development, the roles of the various markers associated with liver stem or progenitor cell potential in humans are largely speculative, and based on studies utilizing animal models and certain patient tissues. Human pluripotent stem cell-based in vitro multistage hepatic differentiation systems may serve as good surrogate models for mimicking normal human liver development, pathogenesis and injury/regeneration studies. Here, we describe the implications of various liver stem or progenitor cell markers and their bipotency (i.e. hepatocytic- and biliary-epithelial cell differentiation), based on the pluripotent stem cell-derived model of human liver development. Future studies using the human cellular model(s) of liver and biliary development will provide more human relevant biological and/or pathological roles of distinct markers expressed in heterogeneous liver stem/progenitor cell populations.

Original languageEnglish (US)
Pages (from-to)1653-1662
Number of pages10
JournalExperimental Biology and Medicine
Volume241
Issue number15
DOIs
StatePublished - Sep 1 2016

Keywords

  • Liver stem cell
  • biliary differentiation
  • bipotency
  • hepatic differentiation
  • hepatoblast
  • human liver development
  • liver progenitor
  • pluripotent stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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