Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice

John R. Corboy, Jeanine M. Buzy, M. Christine Zink, Janice E. Clements

Research output: Contribution to journalArticlepeer-review

Abstract

Infection with the human immunodeficiency virus (HIV) is frequently accompanied by the AIDS (acquired immunodeficiency syndrome) dementia complex. The role of specific HIV genetic elements in the pathogenesis of central nervous system (CNS) disease is not clear. Transgenic mice were constructed that contained the long terminal repeats (LTRs) of two CNS-derived strains and a T cell tropic strain of HIV-1. Only mice generated with CNS-derived LTRs directed expression in the CNS, particularly in neurons. Thus, some strains of HIV-1 have a selective advantage for gene expression in the brain, and neurons can supply the cellular factors necessary for their transcription.

Original languageEnglish (US)
Pages (from-to)1804-1808
Number of pages5
JournalScience
Volume258
Issue number5089
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • General

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