TY - JOUR
T1 - Expression and ontogeny of murine CD2
AU - Sen, Jyoti
AU - Arceci, Robert J.
AU - Jones, William
AU - Burakoff, Steven J.
PY - 1989/7
Y1 - 1989/7
N2 - CD2 was first defined as the erythrocyte rosetting protein on the surface of human T cells. Recently, the rat and murine homologues have been identified by cDNA cloning. In this report we demonstrate that CD2 is expressed on the surface of most adult murine peripheral lymphocytes and thymocytes by indirect immunofluorescence using an anti‐murine CD2 antiserum. The expression of CD2 on murine B cells was unexpected since in rat and human species it has been defined as a T cell‐specific marker. Furthermore, CD2 appears very early on fetal thymocytes during development. The level of surface expression increases from day 13 of gestation to day 17, after which the surface density appears to reach a steady state. Thus, CD2 is expressed on day‐13 thymocytes at the same stage that Thy‐1, Pgp1 and the TcRγ/δ/CD3 complex have been shown to be expressed.
AB - CD2 was first defined as the erythrocyte rosetting protein on the surface of human T cells. Recently, the rat and murine homologues have been identified by cDNA cloning. In this report we demonstrate that CD2 is expressed on the surface of most adult murine peripheral lymphocytes and thymocytes by indirect immunofluorescence using an anti‐murine CD2 antiserum. The expression of CD2 on murine B cells was unexpected since in rat and human species it has been defined as a T cell‐specific marker. Furthermore, CD2 appears very early on fetal thymocytes during development. The level of surface expression increases from day 13 of gestation to day 17, after which the surface density appears to reach a steady state. Thus, CD2 is expressed on day‐13 thymocytes at the same stage that Thy‐1, Pgp1 and the TcRγ/δ/CD3 complex have been shown to be expressed.
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U2 - 10.1002/eji.1830190722
DO - 10.1002/eji.1830190722
M3 - Article
C2 - 2569403
AN - SCOPUS:0024333995
SN - 0014-2980
VL - 19
SP - 1297
EP - 1302
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 7
ER -