Expression and ontogeny of CD2 on murine B cells

Jyoti Sen, Naomi Rosenberg, Steven J. Burakoff

Research output: Contribution to journalArticlepeer-review

Abstract

Expression of CD2 on developing and mature murine B cells was examined by using an antipeptide antiserum (L50). Most Ig-bearing splenic B cells were found to express CD2. Anti-CD5 and anti-B220 mAb divided the peritoneal B cells into two populations expressing high and low levels of these proteins; both populations were found to express uniform levels of CD2. Abelson murine leukemia virus-transformed pre-B cell lines derived from feta liver and adult bone marrow were analyzed to delineate the ontogeny of CD2 in the B cell lineage. The results show that onset of CD2 expression correlates with the presence of cytoplasmic μ-chain. Therefore, the earliest CD2+ pre-B cell in the developing B cell population appears to be the classical pre-B cell.

Original languageEnglish (US)
Pages (from-to)2925-2930
Number of pages6
JournalJournal of Immunology
Volume144
Issue number8
StatePublished - Apr 15 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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