Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain

Koko Ishizuka, Ruriko Igata-Yi, Takemi Kimura, Kunio Hieshima, Toshio Kukita, Yosiaki Kin, Yoshio Misumi, Masaaki Yamamoto, Hisayuki Nomiyama, Retsu Miura, Junichi Takamatsu, Shoichi Katsuragi, Taihei Miyakawa

Research output: Contribution to journalArticle

Abstract

Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.

Original languageEnglish (US)
Pages (from-to)1215-1218
Number of pages4
JournalNeuroreport
Volume8
Issue number5
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Keywords

  • LD78
  • chemokines
  • glial cells
  • macrophage inflammatory protein-1α
  • mental disease
  • neurones
  • schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ishizuka, K., Igata-Yi, R., Kimura, T., Hieshima, K., Kukita, T., Kin, Y., Misumi, Y., Yamamoto, M., Nomiyama, H., Miura, R., Takamatsu, J., Katsuragi, S., & Miyakawa, T. (1997). Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain. Neuroreport, 8(5), 1215-1218. https://doi.org/10.1097/00001756-199703240-00031