Exposure-response relationship between paternal smoking and children's pulmonary function

Scott A. Venners, Xiaobin Wang, Changzhong Chen, Binyan Wang, Jiatong Ni, Yongtang Jin, Jianhua Yang, Zhian Fang, Scott T. Weiss, Xiping Xu

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a cross-sectional study to investigate paternal smoking and children's pulmonary function in rural communities of Anqing, China. Our analysis included 1,718 children 8 to 15 yr of age whose mothers were never-smokers. Multiple linear regression models were used to estimate the effect of paternal smoking on children's pulmonary function, with adjustment for children's age, sex, weight, height, square of height, asthma, and father's education. When compared with children of never-smoking fathers, children of smoking fathers had small, but detectable deficits in FEV1 (-36 ml, SE = 20) and FVC (-37 ml, SE = 22). When children of smoking fathers were subdivided into two subgroups, father smoked < 30 cigarettes/day and ≥ 30 cigarettes/day, we found that children whose fathers smoked ≥ 30 cigarettes/day had the largest deficits in both FEV1 (-79 ml, SE = 30) and FVC (-71 ml, SE = 34). This monotonic exposure-response relationship remained in all strata when we further stratified our analysis by children's sex and asthma status. Our data also suggested that the relationship was greatest among nonasthmatic girls, although neither sex nor asthma interaction terms were statistically significant. We conclude that there is a monotonic exposure-response relationship between paternal smoking and decline of pulmonary function in children in this rural Chinese population.

Original languageEnglish (US)
Pages (from-to)973-976
Number of pages4
JournalAmerican journal of respiratory and critical care medicine
Volume164
Issue number6
DOIs
StatePublished - Sep 15 2001
Externally publishedYes

Keywords

  • Children
  • China
  • Environmental tobacco smoke
  • Paternal smoking
  • Pulmonary function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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