Exposing cell-itary confinement: Understanding the mechanisms of confined single cell migration

Bin Sheng Wong, Panagiotis Mistriotis, K Konstantopoulos

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cells in vivo migrate in a complex microenvironment and are subjected to varying degrees of physical confinement provided by neighboring cells, tissues, and extracellular matrix. The molecular machinery that cells utilize to migrate through confining pores or microtracks shares both similarities and differences with that used in unconfined 2D migration. Depending on the exact properties of the local microenvironment and cell contractile state, cells can adopt distinct phenotypes and employ a wide array of mechanisms to migrate efficiently in confined spaces. Remarkably, these various migration modes are also interconvertible and interconnected, highlighting the plasticity and inherent complexity underlying confined cell migration. In this book chapter, an overview of the different molecular mechanisms utilized by cells to migrate in confinement is presented, with special emphasis on the extrinsic environmental and intrinsic molecular determinants that control the transformation from one mechanism to the other.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages139-157
Number of pages19
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1092
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Machinery
Cell Movement
Plasticity
Tissue
Confined Spaces
Cellular Microenvironment
Extracellular Matrix
Phenotype

Keywords

  • Amoeboid migration
  • Cell blebbing
  • Cell migration
  • Lobopodia
  • Osmotic engine
  • Physical confinement
  • Pseudopodia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wong, B. S., Mistriotis, P., & Konstantopoulos, K. (2018). Exposing cell-itary confinement: Understanding the mechanisms of confined single cell migration. In Advances in Experimental Medicine and Biology (pp. 139-157). (Advances in Experimental Medicine and Biology; Vol. 1092). Springer New York LLC. https://doi.org/10.1007/978-3-319-95294-9_8

Exposing cell-itary confinement : Understanding the mechanisms of confined single cell migration. / Wong, Bin Sheng; Mistriotis, Panagiotis; Konstantopoulos, K.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 139-157 (Advances in Experimental Medicine and Biology; Vol. 1092).

Research output: Chapter in Book/Report/Conference proceedingChapter

Wong, BS, Mistriotis, P & Konstantopoulos, K 2018, Exposing cell-itary confinement: Understanding the mechanisms of confined single cell migration. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1092, Springer New York LLC, pp. 139-157. https://doi.org/10.1007/978-3-319-95294-9_8
Wong BS, Mistriotis P, Konstantopoulos K. Exposing cell-itary confinement: Understanding the mechanisms of confined single cell migration. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 139-157. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-95294-9_8
Wong, Bin Sheng ; Mistriotis, Panagiotis ; Konstantopoulos, K. / Exposing cell-itary confinement : Understanding the mechanisms of confined single cell migration. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 139-157 (Advances in Experimental Medicine and Biology).
@inbook{c4135e0c528d4d9db9251a00935b20da,
title = "Exposing cell-itary confinement: Understanding the mechanisms of confined single cell migration",
abstract = "Cells in vivo migrate in a complex microenvironment and are subjected to varying degrees of physical confinement provided by neighboring cells, tissues, and extracellular matrix. The molecular machinery that cells utilize to migrate through confining pores or microtracks shares both similarities and differences with that used in unconfined 2D migration. Depending on the exact properties of the local microenvironment and cell contractile state, cells can adopt distinct phenotypes and employ a wide array of mechanisms to migrate efficiently in confined spaces. Remarkably, these various migration modes are also interconvertible and interconnected, highlighting the plasticity and inherent complexity underlying confined cell migration. In this book chapter, an overview of the different molecular mechanisms utilized by cells to migrate in confinement is presented, with special emphasis on the extrinsic environmental and intrinsic molecular determinants that control the transformation from one mechanism to the other.",
keywords = "Amoeboid migration, Cell blebbing, Cell migration, Lobopodia, Osmotic engine, Physical confinement, Pseudopodia",
author = "Wong, {Bin Sheng} and Panagiotis Mistriotis and K Konstantopoulos",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/978-3-319-95294-9_8",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "139--157",
booktitle = "Advances in Experimental Medicine and Biology",

}

TY - CHAP

T1 - Exposing cell-itary confinement

T2 - Understanding the mechanisms of confined single cell migration

AU - Wong, Bin Sheng

AU - Mistriotis, Panagiotis

AU - Konstantopoulos, K

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Cells in vivo migrate in a complex microenvironment and are subjected to varying degrees of physical confinement provided by neighboring cells, tissues, and extracellular matrix. The molecular machinery that cells utilize to migrate through confining pores or microtracks shares both similarities and differences with that used in unconfined 2D migration. Depending on the exact properties of the local microenvironment and cell contractile state, cells can adopt distinct phenotypes and employ a wide array of mechanisms to migrate efficiently in confined spaces. Remarkably, these various migration modes are also interconvertible and interconnected, highlighting the plasticity and inherent complexity underlying confined cell migration. In this book chapter, an overview of the different molecular mechanisms utilized by cells to migrate in confinement is presented, with special emphasis on the extrinsic environmental and intrinsic molecular determinants that control the transformation from one mechanism to the other.

AB - Cells in vivo migrate in a complex microenvironment and are subjected to varying degrees of physical confinement provided by neighboring cells, tissues, and extracellular matrix. The molecular machinery that cells utilize to migrate through confining pores or microtracks shares both similarities and differences with that used in unconfined 2D migration. Depending on the exact properties of the local microenvironment and cell contractile state, cells can adopt distinct phenotypes and employ a wide array of mechanisms to migrate efficiently in confined spaces. Remarkably, these various migration modes are also interconvertible and interconnected, highlighting the plasticity and inherent complexity underlying confined cell migration. In this book chapter, an overview of the different molecular mechanisms utilized by cells to migrate in confinement is presented, with special emphasis on the extrinsic environmental and intrinsic molecular determinants that control the transformation from one mechanism to the other.

KW - Amoeboid migration

KW - Cell blebbing

KW - Cell migration

KW - Lobopodia

KW - Osmotic engine

KW - Physical confinement

KW - Pseudopodia

UR - http://www.scopus.com/inward/record.url?scp=85055618080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055618080&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-95294-9_8

DO - 10.1007/978-3-319-95294-9_8

M3 - Chapter

C2 - 30368752

AN - SCOPUS:85055618080

T3 - Advances in Experimental Medicine and Biology

SP - 139

EP - 157

BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

ER -