Explosive Blast Loading on Human 3D Aggregate Minibrains

Nicole E. Zander, Thuvan Piehler, Helena Hogberg, David Pamies

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of primary explosive blast on brain tissue still remain mostly unknown. There are few in vitro models that use real explosives to probe the mechanisms of injury at the cellular level. In this work, 3D aggregates of human brain cells or brain microphysiological system were exposed to military explosives at two different pressures (50 and 100 psi). Results indicate that membrane damage and oxidative stress increased with blast pressure, but cell death remained minimal.

Original languageEnglish (US)
Pages (from-to)1331-1334
Number of pages4
JournalCellular and molecular neurobiology
Volume37
Issue number7
DOIs
StatePublished - Oct 1 2017

Keywords

  • Explosives
  • In vitro model
  • Induced pluripotent stem cells
  • Minibrain
  • Primary blast
  • Traumatic brain injury

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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