TY - JOUR
T1 - Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines
AU - McKelvey, Brittany A.
AU - Zeiger, Martha A.
AU - Umbricht, Christopher B.
N1 - Publisher Copyright:
© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Telomerase regulation, including TERT promoter methylation, has been of long-standing interest to cancer biologists. Rowland et al. have now vastly expanded their ongoing characterization of TERT promoter methylation in cancer cells, analyzing the methylation patterns of 833 cell lines from 23 human cancers. They document a highly conserved pattern of hypomethylation around the proximal promoter, as well as a more heterogeneous region of hypermethylation further upstream, both associated with active TERT expression in cancer cells. They further describe the interplay between activating TERT promoter mutations and allelic methylation and transcription patterns. This valuable dataset represents the most extensive characterization of TERT promoter methylation in cancer cells to date and will help guide the future study of transcriptional regulation of telomerase. Comment on: https://doi.org/10.1002/1878-0261.12786.
AB - Telomerase regulation, including TERT promoter methylation, has been of long-standing interest to cancer biologists. Rowland et al. have now vastly expanded their ongoing characterization of TERT promoter methylation in cancer cells, analyzing the methylation patterns of 833 cell lines from 23 human cancers. They document a highly conserved pattern of hypomethylation around the proximal promoter, as well as a more heterogeneous region of hypermethylation further upstream, both associated with active TERT expression in cancer cells. They further describe the interplay between activating TERT promoter mutations and allelic methylation and transcription patterns. This valuable dataset represents the most extensive characterization of TERT promoter methylation in cancer cells to date and will help guide the future study of transcriptional regulation of telomerase. Comment on: https://doi.org/10.1002/1878-0261.12786.
KW - TERT promoter methylation
KW - TERT promoter mutation
KW - epigenetic regulation
KW - monoallelic gene expression
KW - monoallelic methylation
KW - telomerase reverse transcriptase
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U2 - 10.1002/1878-0261.12798
DO - 10.1002/1878-0261.12798
M3 - Comment/debate
C2 - 32920953
AN - SCOPUS:85091096869
SN - 1574-7891
VL - 14
SP - 2355
EP - 2357
JO - Molecular oncology
JF - Molecular oncology
IS - 10
ER -