Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines

Brittany A. McKelvey, Martha A. Zeiger, Christopher B. Umbricht

Research output: Contribution to journalComment/debatepeer-review

Abstract

Telomerase regulation, including TERT promoter methylation, has been of long-standing interest to cancer biologists. Rowland et al. have now vastly expanded their ongoing characterization of TERT promoter methylation in cancer cells, analyzing the methylation patterns of 833 cell lines from 23 human cancers. They document a highly conserved pattern of hypomethylation around the proximal promoter, as well as a more heterogeneous region of hypermethylation further upstream, both associated with active TERT expression in cancer cells. They further describe the interplay between activating TERT promoter mutations and allelic methylation and transcription patterns. This valuable dataset represents the most extensive characterization of TERT promoter methylation in cancer cells to date and will help guide the future study of transcriptional regulation of telomerase. Comment on: https://doi.org/10.1002/1878-0261.12786.

Original languageEnglish (US)
Pages (from-to)2355-2357
Number of pages3
JournalMolecular oncology
Volume14
Issue number10
DOIs
StatePublished - Oct 1 2020

Keywords

  • TERT promoter methylation
  • TERT promoter mutation
  • epigenetic regulation
  • monoallelic gene expression
  • monoallelic methylation
  • telomerase reverse transcriptase

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Oncology
  • Cancer Research

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