Exploring risk factors for follicular lymphoma

Alexander J. Ambinder, Pareen J. Shenoy, Neha Malik, Alison Maggioncalda, Loretta J. Nastoupil, Christopher R. Flowers

Research output: Contribution to journalReview article

Abstract

Follicular lymphoma (FL) is an indolent malignancy of germinal center B cells with varied incidence across racial groups and geographic regions. Improvements in the classification of non-Hodgkin lymphoma subtypes provide an opportunity to explore associations between environmental exposures and FL incidence. Our paper found that aspects of Western lifestyle including sedentary lifestyle, obesity, and diets high in meat and milk are associated with an increased risk of FL. Diets rich in fruits and vegetables, polyunsaturated fatty acids, vitamin D, and certain antioxidants are inversely associated with FL risk. A medical history of Sjogren's syndrome, influenza vaccination, and heart disease may be associated with FL incidence. Associations between FL and exposure to pesticides, industrial solvents, hair dyes, and alcohol/tobacco were inconsistent. Genetic risk factors include variants at the 6p21.32 region of the MHC II locus, polymorphisms of the DNA repair gene XRCC3, and UV exposure in individuals with certain polymorphisms of the vitamin D receptor. Increasing our understanding of risk factors for FL must involve integrating epidemiological studies of genetics and exposures to allow for the examination of risk factors and interactions between genes and environment.

Original languageEnglish (US)
Article number626035
JournalAdvances in Hematology
Volume2012
DOIs
StatePublished - Oct 17 2012

ASJC Scopus subject areas

  • Hematology

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    Ambinder, A. J., Shenoy, P. J., Malik, N., Maggioncalda, A., Nastoupil, L. J., & Flowers, C. R. (2012). Exploring risk factors for follicular lymphoma. Advances in Hematology, 2012, [626035]. https://doi.org/10.1155/2012/626035