TY - JOUR
T1 - Exploring in vivo placental microstructure in healthy and growth-restricted pregnancies through diffusion-weighted magnetic resonance imaging
AU - Andescavage, Nickie
AU - You, Wonsang
AU - Jacobs, Marni
AU - Kapse, Kushal
AU - Quistorff, Jessica
AU - Bulas, Dorothy
AU - Ahmadzia, Homa
AU - Gimovsky, Alexis
AU - Baschat, Ahmet
AU - Limperopoulos, Catherine
N1 - Funding Information:
Supported by National Institutes of Health ( R01-HL116585 , 1U54HD090257 , UL1TR000075 , KL2TR000076 , 1K23HD092585-01A1 ).
Funding Information:
This work has been supported by National Institutes of Health ( R01-HL116585 , 1U54HD090257 , UL1TR000075 , KL2TR000076 , 1K23HD092585 ).
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/4
Y1 - 2020/4
N2 - Introduction: Gross and microstructural changes in placental development can influence placental function and adversely impact fetal growth and well-being; however, there is a paucity of invivo tools available to reliably interrogate in vivo placental microstructural development. The objective of this study is to characterize invivo placental microstructural diffusion and perfusion in healthy and growth-restricted pregnancies (FGR) using non-invasive diffusion-weighted imaging (DWI). Methods: We prospectively enrolled healthy pregnant women and women whose pregnancies were complicated by FGR. Each woman underwent DWI-MRI between 18 and 40 weeks gestation. Placental measures of small (D) and large (D*) scale diffusion and perfusion (f) were estimated using the intra-voxel incoherent motion (IVIM) model. Results: We studied 137 pregnant women (101 healthy; 36 FGR). D and D* are increased in late-onset FGR, and the placental perfusion fraction, f, is decreased (p < 0.05 for all). Discussion: Placental DWI revealed microstructural alterations of the invivo placenta in FGR, particularly in late-onset FGR. Early and reliable identification of placental pathology in vivo may better guide future interventions.
AB - Introduction: Gross and microstructural changes in placental development can influence placental function and adversely impact fetal growth and well-being; however, there is a paucity of invivo tools available to reliably interrogate in vivo placental microstructural development. The objective of this study is to characterize invivo placental microstructural diffusion and perfusion in healthy and growth-restricted pregnancies (FGR) using non-invasive diffusion-weighted imaging (DWI). Methods: We prospectively enrolled healthy pregnant women and women whose pregnancies were complicated by FGR. Each woman underwent DWI-MRI between 18 and 40 weeks gestation. Placental measures of small (D) and large (D*) scale diffusion and perfusion (f) were estimated using the intra-voxel incoherent motion (IVIM) model. Results: We studied 137 pregnant women (101 healthy; 36 FGR). D and D* are increased in late-onset FGR, and the placental perfusion fraction, f, is decreased (p < 0.05 for all). Discussion: Placental DWI revealed microstructural alterations of the invivo placenta in FGR, particularly in late-onset FGR. Early and reliable identification of placental pathology in vivo may better guide future interventions.
KW - Diffusion weighted imaging (DWI)
KW - Fetal growth restriction (FGR)
KW - Intra-voxel incoherent motion analysis (IVIM)
KW - Magnetic resonance imaging (MRI)
KW - Placenta
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U2 - 10.1016/j.placenta.2020.03.004
DO - 10.1016/j.placenta.2020.03.004
M3 - Article
C2 - 32250735
AN - SCOPUS:85081665075
SN - 0143-4004
VL - 93
SP - 113
EP - 118
JO - Placenta
JF - Placenta
ER -