TY - JOUR
T1 - ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS)
T2 - protocol of a nationwide prospective cohort study
AU - the GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS)
AU - Mauthner, Oliver
AU - Claes, Veerle
AU - Walston, Jeremy
AU - Engberg, Sandra
AU - Binet, Isabelle
AU - Dickenmann, Michael
AU - Golshayan, Déla
AU - Hadaya, Karine
AU - Huynh-Do, Uyen
AU - Calciolari, Stefano
AU - De Geest, Sabina
AU - Berben, Lut
AU - Burkhalter, Hanna
AU - Denhaerynck, Kris
AU - Helmy, Remon
AU - Kirsch, Monika
AU - Leppla, Lynn
AU - Struker, Marian
AU - Boehler, Annette
AU - Gerull, Sabine
AU - Koller, Michael T.
AU - Boely, Elsa
AU - Catana, Emmanuelle
AU - Simcox, Amira
AU - Seiler, Annina
AU - Klaghofer, Richard
AU - Künzler-Heule, Patrizia
AU - Beckmann, Sonja
AU - Achermann, Rita
AU - Amico, Patrizia
AU - Aubert, John David
AU - Baumann, Philippe
AU - Beldi, Guido
AU - Benden, Christian
AU - Berger, Christoph
AU - Bochud, Pierre Yves
AU - Boely, Elsa
AU - Bucher, Heiner
AU - Bühler, Leo
AU - Carell, Thierry
AU - Catana, Emmanuelle
AU - Chalandon, Yves
AU - de Rougemont, Olivier
AU - Duchosal, Michel
AU - Fehr, Thomas
AU - Ferrari-Lacraz, Sylvie
AU - Garzoni, Christian
AU - Soccal, Paola Gasche
AU - Giostra, Emiliano
AU - Halter, Jörg
N1 - Funding Information:
The GERAS study was funded by a research grant of the Swiss Transplant Cohort Study (STCS) in 2015 (FUP073). The STCS provided this funding based on a grant from the Swiss National Research Foundation (grant number 148512); Astellas CH-Europe (unrestricted research grant); Roche CH (unrestricted research grant); Novartis CH (unrestricted research grant). We wholeheartedly thank and express our gratitude to all persons and institutions for providing invaluable support in preparing and conducting this multi-centre nationwide study: five Swiss kidney transplant centres, all kidney transplant recipients who consent to participate in our study; the data collectors; the funding agencies; the STCS Scientific Board and Executive Office; the Clinical Trial Unit of the University Hospital Basel; the laboratories at all participating hospitals; the professional translators of our study documents; statistical support; colleagues and family members
Publisher Copyright:
© 2016 John Wiley & Sons Ltd
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Aim: To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation. Background: For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision-making and medical management. As known risk factors for ‘hard’ clinical outcomes in chronic illness, both require further study in transplantation. Integrating these and other bio-psychosocial factors into a comprehensive pre-transplant patient assessment will provide insights regarding economic implications and may improve risk prediction. Design: A nation-wide multi-centre prospective cohort study nested in the Swiss Transplant Cohort Study. Methods: Our nationally representative convenience sample includes 250 adult kidney transplant recipients. Data sources include the Swiss Transplant Cohort Study and primary data collected at time of transplantation, 6 months, 1 and 2 years post-transplant via established measures (the Montreal Cognitive Assessment, Psychosocial Questionnaire, Fried Frailty Instrument and a blood analysis), investigator-developed instruments and datasets compiled by hospitals’ management control units, sickness funds, the Swiss Federal Statistical Office and the European Renal Association. Descriptive, competing risk survival and mixed effects analyses will be performed. Research Ethics Committee approval was obtained in January 2016. Discussion: This pioneering project jointly examines frailty and mild cognitive impairment from bio-psychosocial and health economic perspectives. Results may significantly inform risk prediction, care tailoring and resource optimization to improve health outcomes in the ageing kidney transplant cohort.
AB - Aim: To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation. Background: For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision-making and medical management. As known risk factors for ‘hard’ clinical outcomes in chronic illness, both require further study in transplantation. Integrating these and other bio-psychosocial factors into a comprehensive pre-transplant patient assessment will provide insights regarding economic implications and may improve risk prediction. Design: A nation-wide multi-centre prospective cohort study nested in the Swiss Transplant Cohort Study. Methods: Our nationally representative convenience sample includes 250 adult kidney transplant recipients. Data sources include the Swiss Transplant Cohort Study and primary data collected at time of transplantation, 6 months, 1 and 2 years post-transplant via established measures (the Montreal Cognitive Assessment, Psychosocial Questionnaire, Fried Frailty Instrument and a blood analysis), investigator-developed instruments and datasets compiled by hospitals’ management control units, sickness funds, the Swiss Federal Statistical Office and the European Renal Association. Descriptive, competing risk survival and mixed effects analyses will be performed. Research Ethics Committee approval was obtained in January 2016. Discussion: This pioneering project jointly examines frailty and mild cognitive impairment from bio-psychosocial and health economic perspectives. Results may significantly inform risk prediction, care tailoring and resource optimization to improve health outcomes in the ageing kidney transplant cohort.
KW - frailty
KW - health economics
KW - kidney transplantation
KW - midwives
KW - mild cognitive impairment
KW - nurses
KW - nursing
KW - older patients
KW - risk prediction, multi-centre prospective cohort study
UR - http://www.scopus.com/inward/record.url?scp=85005992622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85005992622&partnerID=8YFLogxK
U2 - 10.1111/jan.13179
DO - 10.1111/jan.13179
M3 - Article
C2 - 27731953
AN - SCOPUS:85005992622
SN - 0309-2402
VL - 73
SP - 716
EP - 734
JO - Journal of advanced nursing
JF - Journal of advanced nursing
IS - 3
ER -