Exploring difference and overlap between schizophrenia, schizoaffective and bipolar disorders using resting-state brain functional networks

Yuhui Du, Jingyu Liu, Jing Sui, Hao He, Godfrey D. Pearlson, Vince D. Calhoun

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Schizophrenia, schizoaffective and bipolar disorders share some common symptoms. However, the biomarkers underlying those disorders remain unclear. In fact, there is still controversy about the schizoaffective disorder with respect to its validity of independent category and its relationship with schizophrenia and bipolar disorders. In this paper, based on brain functional networks extracted from resting-state fMRI using a recently proposed group information guided ICA (GIG-ICA) method, we explore the biomarkers for discriminating healthy controls, schizophrenia patients, bipolar patients, and patients with two symptom defined subsets of schizoaffective disorder, and then investigate the relationship between different groups. The results demonstrate that the discriminating regions mainly including frontal, parietal, precuneus, cingulate, supplementary motor, cerebellar, insular and supramarginal cortices perform well in distinguishing the different diagnostic groups. The results also suggest that schizoaffective disorder may be an independent disorder, although its subtype characterized by depressive episodes shares more similarity with schizophrenia.

    Original languageEnglish (US)
    Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages1517-1520
    Number of pages4
    ISBN (Electronic)9781424479290
    DOIs
    StatePublished - Nov 2 2014
    Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
    Duration: Aug 26 2014Aug 30 2014

    Publication series

    Name2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

    Other

    Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
    CountryUnited States
    CityChicago
    Period8/26/148/30/14

    ASJC Scopus subject areas

    • Health Informatics
    • Computer Science Applications
    • Biomedical Engineering
    • Medicine(all)

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  • Cite this

    Du, Y., Liu, J., Sui, J., He, H., Pearlson, G. D., & Calhoun, V. D. (2014). Exploring difference and overlap between schizophrenia, schizoaffective and bipolar disorders using resting-state brain functional networks. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 1517-1520). [6943890] (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6943890