Abstract
Mosquito-transmitted diseases impose a growing burden on human health, and current control strategies have proven insufficient to stem the tide. The bacterium Wolbachia is a novel and promising form of control for mosquito-transmitted disease. It manipulates host biology, restricts infection with dengue and other pathogens, and alters host reproduction to promote rapid spread in the field. In this review, we examine how the intimate and diverse relationships formed between Wolbachia and their mosquito hosts can be exploited for disease control purposes. We consider these relationships in the context of recent developments, including successful field trials with Wolbachia-infected mosquitoes to combat dengue, and new Wolbachia infections in key malaria vectors, which have enhanced the disease control prospects of this unique bacterium.
Original language | English (US) |
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Pages (from-to) | 207-218 |
Number of pages | 12 |
Journal | Trends in parasitology |
Volume | 32 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2016 |
Externally published | Yes |
Keywords
- Aedes aegypti
- Dengue
- Disease control
- Host-symbiont interactions
- Malaria
- Wolbachia
ASJC Scopus subject areas
- Parasitology
- Infectious Diseases