Exploitation of auxotrophies and metabolic defects in Toxoplasma as therapeutic approaches

Research output: Contribution to journalReview articlepeer-review

Abstract

Like any obligate intracellular pathogen, the parasite Toxoplasma gondii has lost its capacity for living independently of another organism. Toxoplasma lacks many genes that encode for entire metabolic pathways and has, in return, expanded genes that promote nutrient scavenging to meet its basic metabolic requirements. Although sequestrated in a parasitophorous vacuole and thus insulated from the nutrient-rich host cytosol and organelles by a membrane, T. gondii has evolved efficient strategies to acquire essential metabolites from mammalian cells. This review explores the natural auxotrophies and nutrient scavenging activities of the parasite, emphasising unique transport systems and salvage pathways. We describe the mechanisms deployed by Toxoplasma to modify its parasitophorous vacuole to gain access to host cytosolic molecules and to hijack host organelles to retrieve their nutrient content. From a therapeutic perspective, we survey the different possibilities to starve T. gondii by nutrient depletion or disruption of salvage pathways.

Original languageEnglish (US)
Pages (from-to)109-120
Number of pages12
JournalInternational Journal for Parasitology
Volume44
Issue number2
DOIs
StatePublished - Feb 1 2014

Keywords

  • Apicomplexan parasites
  • Auxotrophy
  • Host cell adaptations
  • Inhibitors of transporters
  • Intracellular parasitism
  • Mechanisms of nutrient diversion
  • Salvage pathways
  • Toxoplasma

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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