Expired air carbon monoxide accumulation and elimination as a function of number of cigarettes smoked

Jack E. Henningfield, Maxine L. Stitzer, Roland R. Griffiths

Research output: Contribution to journalArticle


Eight heavy cigarette smokers smoked varying numbers of cigarettes during sessions of approximately 8 hours in length. Expired air carbon monoxide (CO) levels were determined every 10 minutes during sessions using a portable breath analyzer. Under these conditions, orderly patterns of CO accumulation and elimination were revealed, both within and across subjects, although absolute rates of accumulation and elimination varied considerably across individuals. Peak CO values and the duration of elevation of CO level were directly related to number of cigarettes smoked. In general, the findings support the potential utility of this measure for smoking research and treatment.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalAddictive Behaviors
Issue number3
StatePublished - 1980


ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Toxicology
  • Psychiatry and Mental health

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