TY - JOUR
T1 - Experts’ consensus on intraoperative radiotherapy for pancreatic cancer
AU - Li, Yexiong
AU - Feng, Qinfu
AU - Jin, Jing
AU - Shi, Susheng
AU - Zhang, Zhihui
AU - Che, Xu
AU - Zhang, Jianwei
AU - Chen, Yingtai
AU - Wu, Xiuhong
AU - Chen, Rufu
AU - Li, Shengping
AU - Wang, Jing
AU - Li, Guang
AU - Li, Fei
AU - Dai, Menghua
AU - Zheng, Lei
AU - Wang, Chengfeng
N1 - Funding Information:
Our work was funded by CAMS Initiative Fund for Medical Sciences (CIFMS) (no. 2016-I2M-1-001).
Funding Information:
Our work was funded by CAMS Initiative Fund for Medical Sciences (CIFMS) (no. 2016-I2M-1-001 ).
Publisher Copyright:
© 2019 The Author(s)
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8%–10% of digestive system cancers, and the incidence is increasing. Surgery, chemotherapy, and radiotherapy have been the main treatment methods but are not very effective. However, only 20% of patients have the opportunity to undergo surgical operation. Approximately 30–40% of patients present with locally advanced, unresectable pancreatic cancer because of invasion of mesenteric vessels or adjacent organs. The first patient with unresectable pancreatic cancer was treated with Intraoperative radiotherapy (IORT) in 1959 [1]. Since then, new surgical and radiotherapeutic techniques have been developed, clinical trials have provided new evidence, and intriguing long-term effects have emerged from global metadatabases. IORT has the advantages of more accurate target, better local control rate, less complications, longer survival time and better life quality. During the past decade, IORT has been applied in some hospitals in the world, but there is little agreement on technical details and standards. A guidelines of IORT in pancreatic cancer is therefore necessary and timely. To develop standardized criteria for the application of IORT in pancreatic cancer, the experts from China to discuss treatment methods and arrive at a consensus on the indications, contraindications, and preferred techniques of IORT in pancreatic cancer. This detailed and agreed technical description of IORT may have implications on training, assessment, quality control, and future research.
AB - Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8%–10% of digestive system cancers, and the incidence is increasing. Surgery, chemotherapy, and radiotherapy have been the main treatment methods but are not very effective. However, only 20% of patients have the opportunity to undergo surgical operation. Approximately 30–40% of patients present with locally advanced, unresectable pancreatic cancer because of invasion of mesenteric vessels or adjacent organs. The first patient with unresectable pancreatic cancer was treated with Intraoperative radiotherapy (IORT) in 1959 [1]. Since then, new surgical and radiotherapeutic techniques have been developed, clinical trials have provided new evidence, and intriguing long-term effects have emerged from global metadatabases. IORT has the advantages of more accurate target, better local control rate, less complications, longer survival time and better life quality. During the past decade, IORT has been applied in some hospitals in the world, but there is little agreement on technical details and standards. A guidelines of IORT in pancreatic cancer is therefore necessary and timely. To develop standardized criteria for the application of IORT in pancreatic cancer, the experts from China to discuss treatment methods and arrive at a consensus on the indications, contraindications, and preferred techniques of IORT in pancreatic cancer. This detailed and agreed technical description of IORT may have implications on training, assessment, quality control, and future research.
KW - IORT
KW - Pancreatic cancer
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U2 - 10.1016/j.canlet.2019.01.038
DO - 10.1016/j.canlet.2019.01.038
M3 - Review article
C2 - 30771429
AN - SCOPUS:85061646588
VL - 449
SP - 1
EP - 7
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
ER -