Experimental viral polymyositis: Age dependency and immune responses to ross river virus infection in mice

Research output: Contribution to journalArticlepeer-review

Abstract

Ross River virus (RRV) causes an age-dependent myositis in mice. Infected 4-week-old mice develop no clinical signs, but 1-week-old mice develop weakness and myositis. Humoral and cell-mediated immune responses to RRV in the two age groups are comparable, and immunosuppression does not alter age-dependent resistance to clinical disease. Immunosuppression of 1-week-old mice protracts clinical signs and reduces muscle inflammation but does not alter muscle necrosis or regeneration. These studies suggest that immune responses do not determine age dependency of RRV myositis and that muscle necrosis results from direct viral lysis of muscle fibers.

Original languageEnglish (US)
Pages (from-to)656-661
Number of pages6
JournalNeurology
Volume31
Issue number6
DOIs
StatePublished - Jun 1981

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Experimental viral polymyositis: Age dependency and immune responses to ross river virus infection in mice'. Together they form a unique fingerprint.

Cite this