Experimental vaccine strategies for cancer immunotherapy

Chien Hung Chen, T. C. Wu

Research output: Contribution to journalReview articlepeer-review

Abstract

Recently, cancer immunotherapy has emerged as a therapeutic option for the management of cancer patients. This is based on the fact that our immune system, once activated, is capable of developing specific immunity against neoplastic but not normal cells. Increasing evidence suggests that cell- mediated immunity, particularly T-cell-mediated immunity, is important for the control of tumor cells. Several experimental vaccine strategies have been developed to enhance cell-mediated immunity against tumors. Some of these tumor vaccines have generated promising results in murine tumor systems. In addition, several phase I/II clinical trials using these vaccine strategies have shown extremely encouraging results in patients. In this review, we will discuss many of these promising cancer vaccine strategies. We will pay particular attention to the strategies employing dendritic cells, the central player for tumor vaccine development.

Original languageEnglish (US)
Pages (from-to)231-252
Number of pages22
JournalJournal of biomedical science
Volume5
Issue number4
DOIs
StatePublished - Jan 1 1998

Keywords

  • Antigen
  • Cancer
  • Cytotoxic T lymphocyte
  • Dendritic cell
  • Immunotherapy
  • Tumor immunology
  • Vaccine

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

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