Experimental trichosporon infection in persistently granulocytopenic rabbits: Implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis

Thomas J. Walsh, James W. Lee, Gregory P. Melcher, Eileen Navarro, John Bacher, Diana Callender, Kurt D. Reed, Teresa Wu, Gabriel Lopez-Berestein, Philip A. Pizzo

Research output: Contribution to journalArticle

Abstract

Disseminated Trichosporon infection, an uncommon but emerging opportunistic mycosis due to Trichosporon beigelii, is frequently difficult to diagnose, refractory to treatment, and associated with a high attributable mortality. Models of disseminated and gastrointestinal Trichosporon infection were developed in persistently granulocytopenic rabbits. The patterns of infection resembled those of clinical disease, including cutaneous lesions, chorioretinitis, renal infection, pulmonary infection, and antigenemia cross-reactive with cryptococcal capsular polysaccharide. Antigenemia, an early manifestation of disseminated Trichosporon infection, originated in vivo from a fibrillar extracellular matrix. Trichosporon organisms disseminated from the gastrointestinal tract to visceral tissue in colonized immunosuppressed rabbits, whereas there was no dissemination from the gastrointestinal tract of otherwise normal rabbits. The antifungal triazoles, fluconazole and SCH 39304, were most active; maximum tolerated doses of amphotericin B and liposomal amphotericin B were ineffective. Trichosporon antigenemia declined in response to antifungal therapy. These findings contribute to improved understanding of the pathogenesis, diagnosis, and treatment of disseminated Trichosporon infection.

Original languageEnglish (US)
Pages (from-to)121-133
Number of pages13
JournalJournal of Infectious Diseases
Volume166
Issue number1
DOIs
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Walsh, T. J., Lee, J. W., Melcher, G. P., Navarro, E., Bacher, J., Callender, D., Reed, K. D., Wu, T., Lopez-Berestein, G., & Pizzo, P. A. (1992). Experimental trichosporon infection in persistently granulocytopenic rabbits: Implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis. Journal of Infectious Diseases, 166(1), 121-133. https://doi.org/10.1093/infdis/166.1.121