Experimental trichosporon infection in persistently granulocytopenic rabbits: Implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis

Thomas J. Walsh, James W. Lee, Gregory P. Melcher, Eileen Navarro, John Bacher, Diana Callender, Kurt D. Reed, Teresa Wu, Gabriel Lopez-Berestein, Philip A. Pizzo

Research output: Contribution to journalArticle

Abstract

Disseminated Trichosporon infection, an uncommon but emerging opportunistic mycosis due to Trichosporon beigelii, is frequently difficult to diagnose, refractory to treatment, and associated with a high attributable mortality. Models of disseminated and gastrointestinal Trichosporon infection were developed in persistently granulocytopenic rabbits. The patterns of infection resembled those of clinical disease, including cutaneous lesions, chorioretinitis, renal infection, pulmonary infection, and antigenemia cross-reactive with cryptococcal capsular polysaccharide. Antigenemia, an early manifestation of disseminated Trichosporon infection, originated in vivo from a fibrillar extracellular matrix. Trichosporon organisms disseminated from the gastrointestinal tract to visceral tissue in colonized immunosuppressed rabbits, whereas there was no dissemination from the gastrointestinal tract of otherwise normal rabbits. The antifungal triazoles, fluconazole and SCH 39304, were most active; maximum tolerated doses of amphotericin B and liposomal amphotericin B were ineffective. Trichosporon antigenemia declined in response to antifungal therapy. These findings contribute to improved understanding of the pathogenesis, diagnosis, and treatment of disseminated Trichosporon infection.

Original languageEnglish (US)
Pages (from-to)121-133
Number of pages13
JournalJournal of Infectious Diseases
Volume166
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Trichosporon
Mycoses
Rabbits
Infection
Gastrointestinal Tract
Chorioretinitis
Triazoles
Maximum Tolerated Dose
Fluconazole
Amphotericin B
Cross Infection
Extracellular Matrix
Kidney
Lung
Skin
Mortality

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Experimental trichosporon infection in persistently granulocytopenic rabbits : Implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis. / Walsh, Thomas J.; Lee, James W.; Melcher, Gregory P.; Navarro, Eileen; Bacher, John; Callender, Diana; Reed, Kurt D.; Wu, Teresa; Lopez-Berestein, Gabriel; Pizzo, Philip A.

In: Journal of Infectious Diseases, Vol. 166, No. 1, 1992, p. 121-133.

Research output: Contribution to journalArticle

Walsh, TJ, Lee, JW, Melcher, GP, Navarro, E, Bacher, J, Callender, D, Reed, KD, Wu, T, Lopez-Berestein, G & Pizzo, PA 1992, 'Experimental trichosporon infection in persistently granulocytopenic rabbits: Implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis', Journal of Infectious Diseases, vol. 166, no. 1, pp. 121-133. https://doi.org/10.1093/infdis/166.1.121
Walsh, Thomas J. ; Lee, James W. ; Melcher, Gregory P. ; Navarro, Eileen ; Bacher, John ; Callender, Diana ; Reed, Kurt D. ; Wu, Teresa ; Lopez-Berestein, Gabriel ; Pizzo, Philip A. / Experimental trichosporon infection in persistently granulocytopenic rabbits : Implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis. In: Journal of Infectious Diseases. 1992 ; Vol. 166, No. 1. pp. 121-133.
@article{6909612575eb45e3ad65d0174e0712a3,
title = "Experimental trichosporon infection in persistently granulocytopenic rabbits: Implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis",
abstract = "Disseminated Trichosporon infection, an uncommon but emerging opportunistic mycosis due to Trichosporon beigelii, is frequently difficult to diagnose, refractory to treatment, and associated with a high attributable mortality. Models of disseminated and gastrointestinal Trichosporon infection were developed in persistently granulocytopenic rabbits. The patterns of infection resembled those of clinical disease, including cutaneous lesions, chorioretinitis, renal infection, pulmonary infection, and antigenemia cross-reactive with cryptococcal capsular polysaccharide. Antigenemia, an early manifestation of disseminated Trichosporon infection, originated in vivo from a fibrillar extracellular matrix. Trichosporon organisms disseminated from the gastrointestinal tract to visceral tissue in colonized immunosuppressed rabbits, whereas there was no dissemination from the gastrointestinal tract of otherwise normal rabbits. The antifungal triazoles, fluconazole and SCH 39304, were most active; maximum tolerated doses of amphotericin B and liposomal amphotericin B were ineffective. Trichosporon antigenemia declined in response to antifungal therapy. These findings contribute to improved understanding of the pathogenesis, diagnosis, and treatment of disseminated Trichosporon infection.",
author = "Walsh, {Thomas J.} and Lee, {James W.} and Melcher, {Gregory P.} and Eileen Navarro and John Bacher and Diana Callender and Reed, {Kurt D.} and Teresa Wu and Gabriel Lopez-Berestein and Pizzo, {Philip A.}",
year = "1992",
doi = "10.1093/infdis/166.1.121",
language = "English (US)",
volume = "166",
pages = "121--133",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Experimental trichosporon infection in persistently granulocytopenic rabbits

T2 - Implications for pathogenesis, diagnosis, and treatment of an emerging opportunistic mycosis

AU - Walsh, Thomas J.

AU - Lee, James W.

AU - Melcher, Gregory P.

AU - Navarro, Eileen

AU - Bacher, John

AU - Callender, Diana

AU - Reed, Kurt D.

AU - Wu, Teresa

AU - Lopez-Berestein, Gabriel

AU - Pizzo, Philip A.

PY - 1992

Y1 - 1992

N2 - Disseminated Trichosporon infection, an uncommon but emerging opportunistic mycosis due to Trichosporon beigelii, is frequently difficult to diagnose, refractory to treatment, and associated with a high attributable mortality. Models of disseminated and gastrointestinal Trichosporon infection were developed in persistently granulocytopenic rabbits. The patterns of infection resembled those of clinical disease, including cutaneous lesions, chorioretinitis, renal infection, pulmonary infection, and antigenemia cross-reactive with cryptococcal capsular polysaccharide. Antigenemia, an early manifestation of disseminated Trichosporon infection, originated in vivo from a fibrillar extracellular matrix. Trichosporon organisms disseminated from the gastrointestinal tract to visceral tissue in colonized immunosuppressed rabbits, whereas there was no dissemination from the gastrointestinal tract of otherwise normal rabbits. The antifungal triazoles, fluconazole and SCH 39304, were most active; maximum tolerated doses of amphotericin B and liposomal amphotericin B were ineffective. Trichosporon antigenemia declined in response to antifungal therapy. These findings contribute to improved understanding of the pathogenesis, diagnosis, and treatment of disseminated Trichosporon infection.

AB - Disseminated Trichosporon infection, an uncommon but emerging opportunistic mycosis due to Trichosporon beigelii, is frequently difficult to diagnose, refractory to treatment, and associated with a high attributable mortality. Models of disseminated and gastrointestinal Trichosporon infection were developed in persistently granulocytopenic rabbits. The patterns of infection resembled those of clinical disease, including cutaneous lesions, chorioretinitis, renal infection, pulmonary infection, and antigenemia cross-reactive with cryptococcal capsular polysaccharide. Antigenemia, an early manifestation of disseminated Trichosporon infection, originated in vivo from a fibrillar extracellular matrix. Trichosporon organisms disseminated from the gastrointestinal tract to visceral tissue in colonized immunosuppressed rabbits, whereas there was no dissemination from the gastrointestinal tract of otherwise normal rabbits. The antifungal triazoles, fluconazole and SCH 39304, were most active; maximum tolerated doses of amphotericin B and liposomal amphotericin B were ineffective. Trichosporon antigenemia declined in response to antifungal therapy. These findings contribute to improved understanding of the pathogenesis, diagnosis, and treatment of disseminated Trichosporon infection.

UR - http://www.scopus.com/inward/record.url?scp=0026653402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026653402&partnerID=8YFLogxK

U2 - 10.1093/infdis/166.1.121

DO - 10.1093/infdis/166.1.121

M3 - Article

C2 - 1535092

AN - SCOPUS:0026653402

VL - 166

SP - 121

EP - 133

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -