Experimental studies of antibiotic associated colitis

Research output: Contribution to journalArticle

Abstract

Clostridium difficile has been implicated as the major cause of antibiotic-associated pseudomembranous colitis. The laboratory diagnostic test of choice is a tissue culture assay that demonstrates the presence of a cytopathic toxin neutralized by antitoxin to Clostridium sordelli. This toxin is found in stools from patients with antibiotic-associated pseudomembranous colitis and in stools from patients with antibiotic-associated diarrhea. Neutralization of toxin by antitoxin to C. sordelli appears to represent antigenic cross-reactivity, since broth cultures of C. difficile also contain a cytopathic toxin neutralized by this toxin. Strains of C. difficile are susceptible to vancomycin and the clinical experience with oral administration of this agent shows promising results.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalScandinavian Journal of Infectious Diseases
Volume12
Issue numberSUPPL.22
StatePublished - 1980
Externally publishedYes

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Pseudomembranous Enterocolitis
Clostridium difficile
Clostridium sordellii
Antitoxins
Vancomycin
Routine Diagnostic Tests
Oral Administration
Diarrhea
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)

Cite this

Experimental studies of antibiotic associated colitis. / Bartlett, John.

In: Scandinavian Journal of Infectious Diseases, Vol. 12, No. SUPPL.22, 1980, p. 11-15.

Research output: Contribution to journalArticle

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