Experimental sleep disruption and reward learning: moderating role of positive affect responses

Patrick Hamilton Finan, Alexis E. Whitton, Janelle E. Letzen, Bethany Remeniuk, Mercedes L. Robinson, Michael R. Irwin, Diego A. Pizzagalli, Michael T Smith

Research output: Contribution to journalArticle

Abstract

STUDY OBJECTIVES: Sleep disturbances increase vulnerability for depression, but the mechanisms underlying this relationship are not well known. We investigated the effects of experimental sleep disruption on response bias (RB), a measure of reward learning previously linked to depression, and the moderating role of positive affect responses. METHODS: Participants (N = 42) were healthy adults enrolled in a within-subject crossover sleep disruption experiment that incorporated one night of uninterrupted sleep (US) and one night of forced awakenings (FA) in random order. On the day following each experimental sleep night, participants completed a probabilistic reward task to assess RB, and the Positive and Negative Affect Schedule-X. Participants were subgrouped according to positive affect responses: Preserved Positive Affect (i.e. positive affect scores maintained or increased; n = 15) or Reduced Positive Affect (i.e. positive affect scores decreased; n = 27) following FA. RESULTS: Contrary to our hypotheses, across participants, RB did not significantly differ between the US and FA sleep conditions (p = .67). However, the effect of sleep condition on RB was moderated by positive affect response (p = .01); those with preserved positive affect showed heightened RB following FA, whereas those with reduced positive affect showed diminished RB following FA. Changes in negative affect between US and FA did not moderate RB. CONCLUSION: The inability to preserve positive affect through periods of sleep disruption may be a marker of diminished reward learning capability. Understanding how sleep disruption impacts positive affect responses and reward learning identifies a pathway by which sleep disturbances may confer risk for depression.

Original languageEnglish (US)
JournalSleep
Volume42
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Reward
Sleep
Learning
Depression
Appointments and Schedules

Keywords

  • positive affect
  • reward
  • reward learning
  • sleep
  • sleep disruption

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

Cite this

Experimental sleep disruption and reward learning : moderating role of positive affect responses. / Finan, Patrick Hamilton; Whitton, Alexis E.; Letzen, Janelle E.; Remeniuk, Bethany; Robinson, Mercedes L.; Irwin, Michael R.; Pizzagalli, Diego A.; Smith, Michael T.

In: Sleep, Vol. 42, No. 5, 01.05.2019.

Research output: Contribution to journalArticle

Finan, Patrick Hamilton ; Whitton, Alexis E. ; Letzen, Janelle E. ; Remeniuk, Bethany ; Robinson, Mercedes L. ; Irwin, Michael R. ; Pizzagalli, Diego A. ; Smith, Michael T. / Experimental sleep disruption and reward learning : moderating role of positive affect responses. In: Sleep. 2019 ; Vol. 42, No. 5.
@article{e5e01bd5cba548b5bc22badbd269a641,
title = "Experimental sleep disruption and reward learning: moderating role of positive affect responses",
abstract = "STUDY OBJECTIVES: Sleep disturbances increase vulnerability for depression, but the mechanisms underlying this relationship are not well known. We investigated the effects of experimental sleep disruption on response bias (RB), a measure of reward learning previously linked to depression, and the moderating role of positive affect responses. METHODS: Participants (N = 42) were healthy adults enrolled in a within-subject crossover sleep disruption experiment that incorporated one night of uninterrupted sleep (US) and one night of forced awakenings (FA) in random order. On the day following each experimental sleep night, participants completed a probabilistic reward task to assess RB, and the Positive and Negative Affect Schedule-X. Participants were subgrouped according to positive affect responses: Preserved Positive Affect (i.e. positive affect scores maintained or increased; n = 15) or Reduced Positive Affect (i.e. positive affect scores decreased; n = 27) following FA. RESULTS: Contrary to our hypotheses, across participants, RB did not significantly differ between the US and FA sleep conditions (p = .67). However, the effect of sleep condition on RB was moderated by positive affect response (p = .01); those with preserved positive affect showed heightened RB following FA, whereas those with reduced positive affect showed diminished RB following FA. Changes in negative affect between US and FA did not moderate RB. CONCLUSION: The inability to preserve positive affect through periods of sleep disruption may be a marker of diminished reward learning capability. Understanding how sleep disruption impacts positive affect responses and reward learning identifies a pathway by which sleep disturbances may confer risk for depression.",
keywords = "positive affect, reward, reward learning, sleep, sleep disruption",
author = "Finan, {Patrick Hamilton} and Whitton, {Alexis E.} and Letzen, {Janelle E.} and Bethany Remeniuk and Robinson, {Mercedes L.} and Irwin, {Michael R.} and Pizzagalli, {Diego A.} and Smith, {Michael T}",
year = "2019",
month = "5",
day = "1",
doi = "10.1093/sleep/zsz026",
language = "English (US)",
volume = "42",
journal = "Sleep",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "5",

}

TY - JOUR

T1 - Experimental sleep disruption and reward learning

T2 - moderating role of positive affect responses

AU - Finan, Patrick Hamilton

AU - Whitton, Alexis E.

AU - Letzen, Janelle E.

AU - Remeniuk, Bethany

AU - Robinson, Mercedes L.

AU - Irwin, Michael R.

AU - Pizzagalli, Diego A.

AU - Smith, Michael T

PY - 2019/5/1

Y1 - 2019/5/1

N2 - STUDY OBJECTIVES: Sleep disturbances increase vulnerability for depression, but the mechanisms underlying this relationship are not well known. We investigated the effects of experimental sleep disruption on response bias (RB), a measure of reward learning previously linked to depression, and the moderating role of positive affect responses. METHODS: Participants (N = 42) were healthy adults enrolled in a within-subject crossover sleep disruption experiment that incorporated one night of uninterrupted sleep (US) and one night of forced awakenings (FA) in random order. On the day following each experimental sleep night, participants completed a probabilistic reward task to assess RB, and the Positive and Negative Affect Schedule-X. Participants were subgrouped according to positive affect responses: Preserved Positive Affect (i.e. positive affect scores maintained or increased; n = 15) or Reduced Positive Affect (i.e. positive affect scores decreased; n = 27) following FA. RESULTS: Contrary to our hypotheses, across participants, RB did not significantly differ between the US and FA sleep conditions (p = .67). However, the effect of sleep condition on RB was moderated by positive affect response (p = .01); those with preserved positive affect showed heightened RB following FA, whereas those with reduced positive affect showed diminished RB following FA. Changes in negative affect between US and FA did not moderate RB. CONCLUSION: The inability to preserve positive affect through periods of sleep disruption may be a marker of diminished reward learning capability. Understanding how sleep disruption impacts positive affect responses and reward learning identifies a pathway by which sleep disturbances may confer risk for depression.

AB - STUDY OBJECTIVES: Sleep disturbances increase vulnerability for depression, but the mechanisms underlying this relationship are not well known. We investigated the effects of experimental sleep disruption on response bias (RB), a measure of reward learning previously linked to depression, and the moderating role of positive affect responses. METHODS: Participants (N = 42) were healthy adults enrolled in a within-subject crossover sleep disruption experiment that incorporated one night of uninterrupted sleep (US) and one night of forced awakenings (FA) in random order. On the day following each experimental sleep night, participants completed a probabilistic reward task to assess RB, and the Positive and Negative Affect Schedule-X. Participants were subgrouped according to positive affect responses: Preserved Positive Affect (i.e. positive affect scores maintained or increased; n = 15) or Reduced Positive Affect (i.e. positive affect scores decreased; n = 27) following FA. RESULTS: Contrary to our hypotheses, across participants, RB did not significantly differ between the US and FA sleep conditions (p = .67). However, the effect of sleep condition on RB was moderated by positive affect response (p = .01); those with preserved positive affect showed heightened RB following FA, whereas those with reduced positive affect showed diminished RB following FA. Changes in negative affect between US and FA did not moderate RB. CONCLUSION: The inability to preserve positive affect through periods of sleep disruption may be a marker of diminished reward learning capability. Understanding how sleep disruption impacts positive affect responses and reward learning identifies a pathway by which sleep disturbances may confer risk for depression.

KW - positive affect

KW - reward

KW - reward learning

KW - sleep

KW - sleep disruption

UR - http://www.scopus.com/inward/record.url?scp=85066163550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066163550&partnerID=8YFLogxK

U2 - 10.1093/sleep/zsz026

DO - 10.1093/sleep/zsz026

M3 - Article

C2 - 30927744

AN - SCOPUS:85066163550

VL - 42

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 5

ER -