Experimental simian virus 40 infection of normal and immunosuppressed spider monkeys

G. A. Cole, K. V. Shah

Research output: Contribution to journalArticlepeer-review


The course of SV40 virus infection in 2 groups of spider monkeys, 4 normal and 6 acutely immunosuppressed with cyclophosphamide, was assessed by monitoring individual animals for the appearance of viremia, viruria and virus specific antibodies. Viremia was present in 2 monkeys from each group only on the second day after infection. None of the animals in either group had detectable virus in the urine. Although levels of neutralizing antibodies at 2 weeks post infection did not differ significantly between normal and drug treated monkeys, the treated animals all eventually displayed peak titers 10 times higher on average than those in the normal group. It is suggested that these elevated antibody levels were due to an enhanced immunogenic stimulus resulting from potentiation of virus replication during the period of drug administration. Limited attempts to demonstrate persistence of virus in infected animals were unsuccessful. None of the experimental animals developed tumors.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalActa virologica
Issue number1
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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