Experimental retinal degeneration in the rabbit produced by intraocular iron

P. C. Burger, G. K. Klintworth

Research output: Contribution to journalArticlepeer-review


One of the recognized complications of retained intraocular ferruginous foreign bodies is a retinal degeneration that sometimes results in loss of vision. The exact means by which the iron causes this change is unknown, although a direct toxic effect on the retina is usually incriminated. In the present experiments the morphologic effect of intraocular iron, either as metallic wires or as ferrous ammonium sulfate, on the retina was investigated. The presence of the iron in either form was reproducibly associated with a retinal necrosis involving primarily, over large areas, the photoreceptor cells. The production of a similar degeneration by other investigators with other forms of iron, coupled with the failure to produce this with another metallic wire (chrome), strongly suggests that this process is the result of a toxic effect of iron on the especially susceptible photoreceptor cell.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalLaboratory Investigation
Issue number1
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology


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