Experimental proctitis due to rectal infection with chlamydia trachomatis in nonhuman primates

Thomas C. Quinn, Hugh R. Taylor, Julius Schachter, Thomas C. Quinn, Hugh R. Taylor, Julius Schachter, Thomas C. Quinn, Hugh R. Taylor, Julius Schachter

Research output: Contribution to journalArticlepeer-review

Abstract

To serially examine the immunopathogenesis and histopathology of rectal infection with Chlamydia trachomatis, we inoculated five cynomolgus monkeys with C. trachomatis sero- var E (non-LGV) and five with serovar L2 (LGV). After inoculation, C. trachomatis was isolated from rectal cultures in three of five non-LGV-infected monkeys and in all five LGV-infected monkeys for a period of 10 weeks. LGV-infected monkeys developed a severe hemorrhagic ulcerative proctitis, in contrast to a mild proctitis in the non-LGV-in- fected monkeys. Hyperplasia of lymphoid follicles and a mucosal polymorphonuclear leukocyte and mononuclear cell infiltrate were evident in all infected monkeys. Crypt abscesses with giant cells and a rare granuloma formation were present in two of five LGV- infected monkeys. C. trachomatis inclusions were initially present in epithelial cells and later in tissue histiocytes. Experimental primate infection with C. trachomatis appears to clinically and histopathologically mimic rectal infection in humans and provides a model for immunopathogenesis studies in chlamydial proctitis and granulomatous proctitis.

Original languageEnglish (US)
Pages (from-to)833-841
Number of pages9
JournalJournal of Infectious Diseases
Volume154
Issue number5
DOIs
StatePublished - Nov 1986
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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