@article{48d73be8abb7472483f8bca527ab0dee,
title = "Experimental papilledema produced by cyclocryotherapy",
abstract = "Cyclocryotherapy was a reliable method of producing prolonged decreased intraocular pressure and papilledema in the rhesus monkey. Histologic changes in papilledema caused by decreased pressure were indistinguishable from those in papilledema from increased intracranial pressure. Electron microscopic observations in papilledema after cyclocryotherapy suggested that the principal morphologic alteration in the optic disk is axonal swelling. Additionally, many mitochondria accumulated in some swollen axons. These changes, observed at the ultrastructural level, suggest that alterations of axoplasmic transport may play a significant role in the pathogenesis of swelling of the disk.",
author = "Minckler, {D. S.} and Tso, {M. O.M.}",
note = "Funding Information: From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology (Drs. Minckler and Tso), and the Department of Ophthalmology, George Washington University Medical Center, Washington, D.C. (Dr. Tso). This study was supported in part by National Institutes of Health research grant EY-01163 and by training grant EY-00032, National Eye Institute, Public Health Service. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. In conducting the research described in this report, the investigators adhered to the {"}Guide for Laboratory Animal Facilities and Care,{"} as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences-National Research Council. Reprint requests to M. O. M. Tso, M.D., Armed Forces Institute of Pathology, Washington, DC 20306.",
year = "1976",
month = oct,
doi = "10.1016/0002-9394(76)90545-6",
language = "English (US)",
volume = "82",
pages = "577--589",
journal = "American journal of ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "4",
}