Experimental papilledema produced by cyclocryotherapy

D. S. Minckler, Mark O M Tso

Research output: Contribution to journalArticle


Cyclocryotherapy was a reliable method of producing prolonged decreased intraocular pressure and papilledema in the rhesus monkey. Histologic changes in papilledema caused by decreased pressure were indistinguishable from those in papilledema from increased intracranial pressure. Electron microscopic observations in papilledema after cyclocryotherapy suggested that the principal morphologic alteration in the optic disk is axonal swelling. Additionally, many mitochondria accumulated in some swollen axons. These changes, observed at the ultrastructural level, suggest that alterations of axoplasmic transport may play a significant role in the pathogenesis of swelling of the disk.

Original languageEnglish (US)
Pages (from-to)577-589
Number of pages13
JournalAmerican Journal of Ophthalmology
Issue number4
Publication statusPublished - 1976


ASJC Scopus subject areas

  • Ophthalmology

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