TY - JOUR
T1 - Experimental pancreatitis
T2 - Influence of secretory state of the pancreas
AU - Kimura, Taizo
AU - Zuidema, George D.
AU - Cameronx, John L.
PY - 1980
Y1 - 1980
N2 - The influence of the secretory state of the pancreas on the development of pancreatitis in an isolated, ex vivo, perfused canine pancreas model was evaluated. Free fatty acid infusion was used to induce pancreatitis, and secretin, glucagon, and atropine were administered to influence the secretory state. Despite a 40-fold difference in hourly secretory output, the development of pancreatitis as judged by weight gain, hemoconcentration, amylase value, and arterial blood pressure response was similar in the stimulated, basal, and suppressed states. This study casts further doubt on the role of hypersecretion in the pathogenesis of acute pancreatitis.
AB - The influence of the secretory state of the pancreas on the development of pancreatitis in an isolated, ex vivo, perfused canine pancreas model was evaluated. Free fatty acid infusion was used to induce pancreatitis, and secretin, glucagon, and atropine were administered to influence the secretory state. Despite a 40-fold difference in hourly secretory output, the development of pancreatitis as judged by weight gain, hemoconcentration, amylase value, and arterial blood pressure response was similar in the stimulated, basal, and suppressed states. This study casts further doubt on the role of hypersecretion in the pathogenesis of acute pancreatitis.
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M3 - Article
C2 - 6159693
AN - SCOPUS:0019148682
SN - 0039-6060
VL - 88
SP - 661
EP - 666
JO - Surgery (United States)
JF - Surgery (United States)
IS - 5
ER -