Experimental pancreatitis: Influence of secretory state of the pancreas

Taizo Kimura, George D. Zuidema, John L. Cameronx

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of the secretory state of the pancreas on the development of pancreatitis in an isolated, ex vivo, perfused canine pancreas model was evaluated. Free fatty acid infusion was used to induce pancreatitis, and secretin, glucagon, and atropine were administered to influence the secretory state. Despite a 40-fold difference in hourly secretory output, the development of pancreatitis as judged by weight gain, hemoconcentration, amylase value, and arterial blood pressure response was similar in the stimulated, basal, and suppressed states. This study casts further doubt on the role of hypersecretion in the pathogenesis of acute pancreatitis.

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalSurgery (United States)
Volume88
Issue number5
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Surgery

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