It has been suggested that ischaemia is an important factor in the conversion of oedematous to haemorrhagic pancreatitis. In the isolated perfused canine pancreas experimental oedematous pancreatitis was induced by two different techniques. These models of pancreatitis were subjected to ischaemia by hypoxia and by decreasing blood flow. The results demonstrate that relative ischaemia alone does not result in progression of oedematous to haemorrhagic pancreatitis. It is therefore probable that ischaemia is only one of several factors which contribute to exacerbation of clinical pancreatitis.
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