TY - JOUR
T1 - Experimental malaria
T2 - Effects upon the immune response to different antigens
AU - Barker, Lee R.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1971/1
Y1 - 1971/1
N2 - At the height of a malaria infection, mice were injected with either sheep erythrocytes (SRBCs) or phage particles, and the antibody response was followed. The response to SRBCs was completely suppressed, but there was a normal response to phage particles, and antibody to the malaria parasites appeared. It is possible that the selective suppression of the response to SRBCs in infected mice was caused by impairment of the processing of other large particulate antigens or by depletion of the population of lymphoid cells sensitive to SRBCs.
AB - At the height of a malaria infection, mice were injected with either sheep erythrocytes (SRBCs) or phage particles, and the antibody response was followed. The response to SRBCs was completely suppressed, but there was a normal response to phage particles, and antibody to the malaria parasites appeared. It is possible that the selective suppression of the response to SRBCs in infected mice was caused by impairment of the processing of other large particulate antigens or by depletion of the population of lymphoid cells sensitive to SRBCs.
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U2 - 10.1093/infdis/123.1.99
DO - 10.1093/infdis/123.1.99
M3 - Article
C2 - 5543222
AN - SCOPUS:0014986717
VL - 123
SP - 99
EP - 101
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -