Experimental investigation of needles, syringes and techniques for intravitreal injections

Vinicius S. De Stefano, Jose Jk Abechain, Luiz Fs de Almeida, Diego M. Verginassi, Eduardo B. Rodrigues, Edna Freymuller, Maurício Maia, Octaviano Magalhaes, Quan D. Nguyen, Michel E. Farah

Research output: Contribution to journalArticle

Abstract

Background: To assess the techniques and materials used in intravitreal injections. Design: Descriptive study realized at the Vision Institute of the Federal University of São Paulo, Brazil. Samples: Different brands of needles and syringes, as well as enucleated porcine eyeballs. Methods: The ultra-structures of commonly used needles were analysed by scanning electron microscope, and they were compared using different criteria, such as irregularities and debris from the lubrication process. The scleral incision was also assessed using needles of different brands and sizes. Accuracies in drug administration were studied by comparing the residual and delivered volume of needles and also by the analysis of reflux after intravitreal injections. Main Outcome Measures: Efficiency and quality of materials used in intravitreal injections. Results: Ultra-structure analyses showed that all needles had different types of irregularities. Some photographs showed debris from the lubrication process, especially in BD needles. Scleral incision analysis showed a tendency of reducing the ocular damage with increasing gauge (P=0.024). The investigation of delivery accuracy showed that almost all needles underdosed the amount injected (P

Original languageEnglish (US)
Pages (from-to)236-242
Number of pages7
JournalClinical and Experimental Ophthalmology
Volume39
Issue number3
DOIs
StatePublished - Apr 2011

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Intravitreal Injections
Syringes
Needles
Lubrication
Residual Volume
Brazil
Swine
Outcome Assessment (Health Care)
Electrons
Pharmaceutical Preparations

Keywords

  • Intravitreal injection
  • Needle
  • Retinal pharmacotherapy
  • Vitreal reflux
  • Vitreoretinal surgery

ASJC Scopus subject areas

  • Ophthalmology

Cite this

De Stefano, V. S., Abechain, J. J., de Almeida, L. F., Verginassi, D. M., Rodrigues, E. B., Freymuller, E., ... Farah, M. E. (2011). Experimental investigation of needles, syringes and techniques for intravitreal injections. Clinical and Experimental Ophthalmology, 39(3), 236-242. https://doi.org/10.1111/j.1442-9071.2010.02447.x

Experimental investigation of needles, syringes and techniques for intravitreal injections. / De Stefano, Vinicius S.; Abechain, Jose Jk; de Almeida, Luiz Fs; Verginassi, Diego M.; Rodrigues, Eduardo B.; Freymuller, Edna; Maia, Maurício; Magalhaes, Octaviano; Nguyen, Quan D.; Farah, Michel E.

In: Clinical and Experimental Ophthalmology, Vol. 39, No. 3, 04.2011, p. 236-242.

Research output: Contribution to journalArticle

De Stefano, VS, Abechain, JJ, de Almeida, LF, Verginassi, DM, Rodrigues, EB, Freymuller, E, Maia, M, Magalhaes, O, Nguyen, QD & Farah, ME 2011, 'Experimental investigation of needles, syringes and techniques for intravitreal injections', Clinical and Experimental Ophthalmology, vol. 39, no. 3, pp. 236-242. https://doi.org/10.1111/j.1442-9071.2010.02447.x
De Stefano VS, Abechain JJ, de Almeida LF, Verginassi DM, Rodrigues EB, Freymuller E et al. Experimental investigation of needles, syringes and techniques for intravitreal injections. Clinical and Experimental Ophthalmology. 2011 Apr;39(3):236-242. https://doi.org/10.1111/j.1442-9071.2010.02447.x
De Stefano, Vinicius S. ; Abechain, Jose Jk ; de Almeida, Luiz Fs ; Verginassi, Diego M. ; Rodrigues, Eduardo B. ; Freymuller, Edna ; Maia, Maurício ; Magalhaes, Octaviano ; Nguyen, Quan D. ; Farah, Michel E. / Experimental investigation of needles, syringes and techniques for intravitreal injections. In: Clinical and Experimental Ophthalmology. 2011 ; Vol. 39, No. 3. pp. 236-242.
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