TY - JOUR
T1 - Experimental infection of anole lizards (Anolis carolinensis) with Mycobacterium ulcerans by the subcutaneous route
AU - Marcus, L. C.
AU - Stottmeier, K. D.
AU - Morrow, R. H.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1975
Y1 - 1975
N2 - To test whether herpetofauna could be a laboratory model for M. ulcerans, 21 anole lizards were inoculated s.c. with viable M. ulcerans, 21 with autoclaved organisms, and 14 with an aqueous solution of 0.01% Tween 80. M. ulcerans was recovered in culture from the slowly progressive lesions which developed at the inoculation site in lizards receiving the viable bacteria. Progressive lesions did not occur in the two control groups. Three patterns of inflammatory response to viable M. ulcerans were observed: 14 lizards developed a diffuse, granulomatous reaction in which acid fast bacilli (AFB) were predominantly intracellular; 1 developed focal, encapsulated granulomas; 5 developed a diffuse, necrotizing granulomatous response in which most AFB were extracellular, similar to the characteristic lesion found in human infections.
AB - To test whether herpetofauna could be a laboratory model for M. ulcerans, 21 anole lizards were inoculated s.c. with viable M. ulcerans, 21 with autoclaved organisms, and 14 with an aqueous solution of 0.01% Tween 80. M. ulcerans was recovered in culture from the slowly progressive lesions which developed at the inoculation site in lizards receiving the viable bacteria. Progressive lesions did not occur in the two control groups. Three patterns of inflammatory response to viable M. ulcerans were observed: 14 lizards developed a diffuse, granulomatous reaction in which acid fast bacilli (AFB) were predominantly intracellular; 1 developed focal, encapsulated granulomas; 5 developed a diffuse, necrotizing granulomatous response in which most AFB were extracellular, similar to the characteristic lesion found in human infections.
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U2 - 10.4269/ajtmh.1975.24.649
DO - 10.4269/ajtmh.1975.24.649
M3 - Article
C2 - 1155700
AN - SCOPUS:0016698321
SN - 0002-9637
VL - 24
SP - 649
EP - 655
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 4
ER -