Experimental infection of anole lizards (Anolis carolinensis) with Mycobacterium ulcerans by the subcutaneous route

L. C. Marcus, K. D. Stottmeier, R. H. Morrow

Research output: Contribution to journalArticle

Abstract

To test whether herpetofauna could be a laboratory model for M. ulcerans, 21 anole lizards were inoculated s.c. with viable M. ulcerans, 21 with autoclaved organisms, and 14 with an aqueous solution of 0.01% Tween 80. M. ulcerans was recovered in culture from the slowly progressive lesions which developed at the inoculation site in lizards receiving the viable bacteria. Progressive lesions did not occur in the two control groups. Three patterns of inflammatory response to viable M. ulcerans were observed: 14 lizards developed a diffuse, granulomatous reaction in which acid fast bacilli (AFB) were predominantly intracellular; 1 developed focal, encapsulated granulomas; 5 developed a diffuse, necrotizing granulomatous response in which most AFB were extracellular, similar to the characteristic lesion found in human infections.

Original languageEnglish (US)
Pages (from-to)649-655
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume24
Issue number4
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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