@article{05a68493caed46d0894339a601744c5a,
title = "Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus",
abstract = "Suitable animal models are needed to study monkeypox virus (MPXV) as human monkeypox clinically resembles smallpox and MPXV is a zoonotic and potential bioterroristic agent. We have demonstrated that a species of African dormice, Graphiurus kelleni, is susceptible to a lethal infection of MPXV and that MPXV replicated in multiple organs of this species. Following intranasal administration, MPXV replicated locally in the nasal mucosa causing necrosis and hemorrhage with subsequent systemic spread to lymph nodes, spleen, liver, and other tissues where it caused severe necrosis and/or hemorrhage leading to death. The dormouse model was validated for testing prophylactic (Dryvax vaccine) and therapeutic (cidofovir) test articles against intranasal challenges with MPXV.",
keywords = "Cidofovir, Dormouse, Dryvax, Graphiurus kelleni, MPXV-ZAI-79, Monkeypox virus, Smallpox, Variola",
author = "Schultz, {Denise A.} and Sagartz, {John E.} and Huso, {David L.} and Buller, {R. Mark L.}",
note = "Funding Information: We are grateful for Gail Dick of Montpelier, Ohio and Roger Prewett of Hopedale, Illinois for their assistance. We are also grateful for Dr. Mary Ellen Holden-Musser of Charleston, South Carolina for her expertise in the taxonomic identification of the African dormice species maintained in the breeding colony at Saint Louis University. We would like to thank Jill Schriewer, Erin Touchette, Jennifer Stabenow, and the Insectarium at the Saint Louis Zoo for their technical assistance. This work was supported by grant R21-AI061512-01 from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH), grant U54-AI057160 from the NAID, the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (MRCE), and grant T32-RR007002 from the National Center for Research Resources (NCRR) of the NIH.",
year = "2009",
month = jan,
day = "5",
doi = "10.1016/j.virol.2008.09.025",
language = "English (US)",
volume = "383",
pages = "86--92",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",
}