Experimental induction of crystalluria in rats using mini-osmotic pumps

Saeed R. Khan, Birdwell Finlayson, Raymond L. Hackett

Research output: Contribution to journalArticlepeer-review

Abstract

Crystalluria was induced in male Sprague-Dawley rats by implanting potassium-oxalate-containing miniosmotic pumps. Urine of all experimental animals had abundant crystals of calcium oxalate, hydroxypatite, struvite, and calcium phosphate. These crystals were similar in morphology to the crystals found in human crystaluria. Histological examination of kidneys and tissue samples from other organs revealed no abnormality. One group of animals was injected with sodium oxalate in addition to implantation of potassium-oxalate-containing mini-osmotic pumps. Bladder urine from these animals contained calcium oxalate microstones and their kidneys had deposits of calcium oxalate crystals.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalUrological Research
Volume11
Issue number5
DOIs
StatePublished - Nov 1983
Externally publishedYes

Keywords

  • Calcium oxalate
  • Crystalluria
  • Mini-osmotic pumps
  • Urinary crystal morphology

ASJC Scopus subject areas

  • Urology

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