Experimental hypertension: the effects of chemical ablation of the renal papilla on the blood pressure of rats with and without silver clip hypertension

R. H. Heptinstall, D. C. Salyer, W. R. Salyer

Research output: Contribution to journalArticle

Abstract

Because of the ease with which ablation of the renal papilla of the rat can be effected by chemical means (bromoethylamine hydrobromide), a study was carried out to determine the effects of this ablation on the blood pressure. Significant elevation was found, lending support to the idea of the antihypertensive role of the renal medulla. Constriction of one renal artery of rats with their papillae removed resulted in a more rapid and greater elevation of pressure than the same procedure in rats with their papillae intact. The rise in pressure approximated the sum of the rises caused by removal of the papilla alone and by renal artery constriction alone, consistent with the idea of 2 mechanisms being at work in this model.

Original languageEnglish (US)
Pages (from-to)297-307
Number of pages11
JournalAmerican Journal of Pathology
Volume78
Issue number2
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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