Experimental human gonococcal urethritis: 250 neisseria gonorrhoeae ms11mkc are infective

Herman Schneider, Alan S. Cross, Robert A. Kuschner, David N. Taylor, Jerald C. Sadoff, John W. Boslego, Carolyn D. Deal

Research output: Contribution to journalArticlepeer-review


Neisseria gonorrhoeae MS11mkA (mkA) expressesone 3.6-kDa lipooligosaccharide (LOS). Variant MS11mkC (mkC), expressing four larger LOSs, occurs in vitro among mkA at a frequency of 10â ˆ3 Infectivity of these variants was compared in 2 groups of volunteers inoculated with â ˆ40,000 piliated, Opaâ ˆ gonococci of either strain. The mkC variant infected 5 of 5 while mkA infected only 2 (40%) of 5. Gonococci recovered from the mkA infections showed a transition toward the mkC LOS phenotype. The mkA inoculum contained â ˆ 40 mkC gonococci. These data confirmed earlier studies and suggested that small numbers of mkC gonococci would be infective. This hypothesis was tested in three more experiments. In two, volunteers were inoculated with 250 or 1250 mkC, infecting 3 of 7 in each group, and in the third, 1600 mkC infected 2 of 6, resulting in a total of 8 of 20 infected by â

Original languageEnglish (US)
Pages (from-to)180-185
Number of pages6
JournalJournal of Infectious Diseases
Issue number1
StatePublished - Jul 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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