@article{a79417a9690446019b125a967e2aa10f,
title = "Experimental Hepatitis E: Pathogenesis in Cynomolgus Macaques (Macaca fascicularis)",
abstract = "The pathogenesis of experimental hepatitis E has not been thoroughly investigated. The purpose of this study was to more accurately document the events in this disease. Cynomolgus macaques were inoculated intravenously with bile or feces containing hepatitis E virus (HEV). Serum, bile, and liver specimens were evaluated with light microscopy, immune electron microscopy, immunofluorescence microscopy, EIA, and polymerase chain reaction. In the third week, there were histopathologic changes and HEV antigen (HEVAg) in liver, HEV in bile, and alanine aminotransferase (ALT) elevations. Widespread pathologic changes were detected during the fourth week and antibody to HEV (anti-HEV) and peak ALT values in the fifth or sixth week. By the sixth week, HEVAg had disappeared but pathologic changes persisted. This study supports the concept that experimental hepatitis E has an initial phase in which hepatic HEV replication is accompanied by the onset of hepatitis and a later phase in which the appearance ofanti-HEV is accompanied by progression of the hepatitis.",
author = "Longer, {Charles F.} and Denny, {Stephen L.} and Caudill, {Jeffrey D.} and Miele, {Thomas A.} and Asher, {Ludmila V.S.} and Myint, {K. S.A.} and Huang, {Chiao Chain} and Engler, {Walter F.} and LeDuc, {James W.} and Binn, {Leonard N.} and Ticehurst, {John R.} and Longer, {Charles F.} and Denny, {Stephen L.} and Caudill, {Jeffrey D.} and Miele, {Thomas A.} and Asher, {Ludmila V.S.} and Myint, {K. S.A.} and Huang, {Chiao Chain} and Engler, {Walter F.} and LeDuc, {James W.} and Binn, {Leonard N.} and Longer, {Charles F.} and Denny, {Stephen L.} and Caudill, {Jeffrey D.} and Miele, {Thomas A.} and Asher, {Ludmila V.S.} and Myint, {K. S.A.} and Huang, {Chiao Chain} and Engler, {Walter F.} and LeDuc, {James W.} and Binn, {Leonard N.} and Longer, {Charles F.} and Denny, {Stephen L.} and Caudill, {Jeffrey D.} and Miele, {Thomas A.} and Asher, {Ludmila V.S.} and Myint, {K. S.A.} and Huang, {Chiao Chain} and Engler, {Walter F.} and LeDuc, {James W.} and Binn, {Leonard N.} and Denny, {Stephen L.} and LeDuc, {James W.}",
note = "Funding Information: Financial support: US Army Medical Research and Development Command (contracts DAMDI7-90-M-S760 and DAMDI7-90-M-S76I with the American Registry of Pathology and contract DAMDI7-90-C-0092 with Genelabs Inc.).",
year = "1993",
month = sep,
day = "1",
doi = "10.1093/infdis/168.3.602",
language = "English (US)",
volume = "168",
pages = "602--609",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",
}