Experimental cryptorchism: Effect on serum LH and FSH in the rat

Patrick Walsh, Ronald S. Swerdloff

Research output: Contribution to journalArticle

Abstract

The effects of cryptorchism on testis weight and histology, ventral prostate weight (VPW), and serum LH and FSH were assessed in rats 49 days of age. Rats 49 days of age have elevated FSH levels which fall to adult range when mature testis weight is achieved. Bilateral crytorchism producted: 1. histological changes in the testes by 3 days and a final reduction of testis weight of 75%; 2. a reduction of VPW of 40%; and 3. elevations of both serum LH and FSH by 4 days; serum FSH did not increase to castrate levels. It is concluded: 1. because serum FSH levels correlate with testicular maturation, some product of the germinal epithelium may selectively regulate FSH secretion; 2. because cryptorchism destroys the germinal epithelium but dose not elevate FSH to the castrate range, spermatogenic activity is not the sole regulator of FSH; and 3. because cryptorchism damages both the gametogenic and androgenic functions of the testes, it will not provide a model for studies of selective FSH regulation.

Original languageEnglish (US)
Pages (from-to)22-26
Number of pages5
JournalUrological Research
Volume1
Issue number1
DOIs
StatePublished - Jan 1973
Externally publishedYes

Fingerprint

Cryptorchidism
Testis
Weights and Measures
Serum
Prostate
Epithelium
Weight Loss
Histology

Keywords

  • anterior pituitary
  • cryptorchism
  • gonadotropins
  • spermatogenesis
  • Testis

ASJC Scopus subject areas

  • Urology

Cite this

Experimental cryptorchism : Effect on serum LH and FSH in the rat. / Walsh, Patrick; Swerdloff, Ronald S.

In: Urological Research, Vol. 1, No. 1, 01.1973, p. 22-26.

Research output: Contribution to journalArticle

Walsh, Patrick ; Swerdloff, Ronald S. / Experimental cryptorchism : Effect on serum LH and FSH in the rat. In: Urological Research. 1973 ; Vol. 1, No. 1. pp. 22-26.
@article{d22a473587804492a7b9d6bbb7c57bac,
title = "Experimental cryptorchism: Effect on serum LH and FSH in the rat",
abstract = "The effects of cryptorchism on testis weight and histology, ventral prostate weight (VPW), and serum LH and FSH were assessed in rats 49 days of age. Rats 49 days of age have elevated FSH levels which fall to adult range when mature testis weight is achieved. Bilateral crytorchism producted: 1. histological changes in the testes by 3 days and a final reduction of testis weight of 75{\%}; 2. a reduction of VPW of 40{\%}; and 3. elevations of both serum LH and FSH by 4 days; serum FSH did not increase to castrate levels. It is concluded: 1. because serum FSH levels correlate with testicular maturation, some product of the germinal epithelium may selectively regulate FSH secretion; 2. because cryptorchism destroys the germinal epithelium but dose not elevate FSH to the castrate range, spermatogenic activity is not the sole regulator of FSH; and 3. because cryptorchism damages both the gametogenic and androgenic functions of the testes, it will not provide a model for studies of selective FSH regulation.",
keywords = "anterior pituitary, cryptorchism, gonadotropins, spermatogenesis, Testis",
author = "Patrick Walsh and Swerdloff, {Ronald S.}",
year = "1973",
month = "1",
doi = "10.1007/BF00254760",
language = "English (US)",
volume = "1",
pages = "22--26",
journal = "Urolithiasis",
issn = "2194-7228",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Experimental cryptorchism

T2 - Effect on serum LH and FSH in the rat

AU - Walsh, Patrick

AU - Swerdloff, Ronald S.

PY - 1973/1

Y1 - 1973/1

N2 - The effects of cryptorchism on testis weight and histology, ventral prostate weight (VPW), and serum LH and FSH were assessed in rats 49 days of age. Rats 49 days of age have elevated FSH levels which fall to adult range when mature testis weight is achieved. Bilateral crytorchism producted: 1. histological changes in the testes by 3 days and a final reduction of testis weight of 75%; 2. a reduction of VPW of 40%; and 3. elevations of both serum LH and FSH by 4 days; serum FSH did not increase to castrate levels. It is concluded: 1. because serum FSH levels correlate with testicular maturation, some product of the germinal epithelium may selectively regulate FSH secretion; 2. because cryptorchism destroys the germinal epithelium but dose not elevate FSH to the castrate range, spermatogenic activity is not the sole regulator of FSH; and 3. because cryptorchism damages both the gametogenic and androgenic functions of the testes, it will not provide a model for studies of selective FSH regulation.

AB - The effects of cryptorchism on testis weight and histology, ventral prostate weight (VPW), and serum LH and FSH were assessed in rats 49 days of age. Rats 49 days of age have elevated FSH levels which fall to adult range when mature testis weight is achieved. Bilateral crytorchism producted: 1. histological changes in the testes by 3 days and a final reduction of testis weight of 75%; 2. a reduction of VPW of 40%; and 3. elevations of both serum LH and FSH by 4 days; serum FSH did not increase to castrate levels. It is concluded: 1. because serum FSH levels correlate with testicular maturation, some product of the germinal epithelium may selectively regulate FSH secretion; 2. because cryptorchism destroys the germinal epithelium but dose not elevate FSH to the castrate range, spermatogenic activity is not the sole regulator of FSH; and 3. because cryptorchism damages both the gametogenic and androgenic functions of the testes, it will not provide a model for studies of selective FSH regulation.

KW - anterior pituitary

KW - cryptorchism

KW - gonadotropins

KW - spermatogenesis

KW - Testis

UR - http://www.scopus.com/inward/record.url?scp=0015560357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015560357&partnerID=8YFLogxK

U2 - 10.1007/BF00254760

DO - 10.1007/BF00254760

M3 - Article

C2 - 4149499

AN - SCOPUS:0015560357

VL - 1

SP - 22

EP - 26

JO - Urolithiasis

JF - Urolithiasis

SN - 2194-7228

IS - 1

ER -