Experimental central nervous system phaeohyphomycosis following intranasal inoculation of Xylohypha bantiana in cortisone-treated mice

Dennis M. Dixon, William G. Merz, Herbert L. Elliott, Stephen Macleay

Research output: Contribution to journalArticle

Abstract

Experimental central nervous system (CNS) phaeohyphomycosis was established in cortisone-treated mice following intranasal exposure to conidia of Xylohypha bantiana (Cladosporium bantianum, C. trichoides). X. bantiana was recovered from the lungs of 78% of intranasally inoculated normal mice sacrificed within the first 3 days of infection and from 15% at day 28. The fungus was not recovered from the brains of normal mice. In contrast, X. bantiana was recovered from only 33% of the lungs of cortisone-treated mice within the first 3 days of infection. However, the fungus was recovered from the brains of 11% of cortisone-treated mice sacrificed or dying over a 28 day period. Histologically and temporally the CNS disease in cortisone-treated, intranasally inoculated mice was consistent with hematogenous dissemination from a primary pulmonary focus.

Original languageEnglish (US)
Pages (from-to)145-153
Number of pages9
JournalMycopathologia
Volume100
Issue number3
DOIs
StatePublished - Dec 1 1987

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Keywords

  • Cladosporium bantianum
  • Cladosporium trichoides dematiaceous fungus
  • neurotropism
  • pulmonary infection
  • respiratory infection
  • systemic mycosis

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology
  • Agronomy and Crop Science
  • veterinary (miscalleneous)

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