Experimental central nervous system phaeohyphomycosis following intranasal inoculation of Xylohypha bantiana in cortisone-treated mice

Dennis M. Dixon, William G. Merz, Herbert L. Elliott, Stephen Macleay

Research output: Contribution to journalArticle

Abstract

Experimental central nervous system (CNS) phaeohyphomycosis was established in cortisone-treated mice following intranasal exposure to conidia of Xylohypha bantiana (Cladosporium bantianum, C. trichoides). X. bantiana was recovered from the lungs of 78% of intranasally inoculated normal mice sacrificed within the first 3 days of infection and from 15% at day 28. The fungus was not recovered from the brains of normal mice. In contrast, X. bantiana was recovered from only 33% of the lungs of cortisone-treated mice within the first 3 days of infection. However, the fungus was recovered from the brains of 11% of cortisone-treated mice sacrificed or dying over a 28 day period. Histologically and temporally the CNS disease in cortisone-treated, intranasally inoculated mice was consistent with hematogenous dissemination from a primary pulmonary focus.

Original languageEnglish (US)
Pages (from-to)145-153
Number of pages9
JournalMycopathologia
Volume100
Issue number3
DOIs
StatePublished - Dec 1987

Fingerprint

Cerebral Phaeohyphomycosis
cortisone
Cortisone
central nervous system
mice
lungs
Lung
Fungi
Cladosporium
brain
central nervous system diseases
fungi
Fungal Spores
Central Nervous System Diseases
Brain
Infection
infection
conidia

Keywords

  • Cladosporium bantianum
  • Cladosporium trichoides dematiaceous fungus
  • neurotropism
  • pulmonary infection
  • respiratory infection
  • systemic mycosis

ASJC Scopus subject areas

  • Plant Science
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Experimental central nervous system phaeohyphomycosis following intranasal inoculation of Xylohypha bantiana in cortisone-treated mice. / Dixon, Dennis M.; Merz, William G.; Elliott, Herbert L.; Macleay, Stephen.

In: Mycopathologia, Vol. 100, No. 3, 12.1987, p. 145-153.

Research output: Contribution to journalArticle

Dixon, Dennis M. ; Merz, William G. ; Elliott, Herbert L. ; Macleay, Stephen. / Experimental central nervous system phaeohyphomycosis following intranasal inoculation of Xylohypha bantiana in cortisone-treated mice. In: Mycopathologia. 1987 ; Vol. 100, No. 3. pp. 145-153.
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