Experimental brush-evoked allodynia activates posterior parietal cortex

Nanna Witting, R. C. Kupers, P. Svensson, Odont L. Arendt-Nielsen, A. Gjedde, T. S. Jensen

Research output: Contribution to journalArticle

Abstract

Objective: To study the brain activation pattern of coexisting experimental ongoing pain and brush-evoked allodynia (pain evoked by innocuous brush) with the use of PET. Background: Neuropathic pain usually has two essential phenomena: ongoing pain and brush-evoked allodynia, which coexist and may influence each other. Capsaicin induces both ongoing pain and brush-evoked allodynia. Methods: Eight healthy right-handed volunteers participated in eight H215O PET scans with two blocks of four randomized conditions: 1) rest, 2) brush, 3) capsaicin pain, and 4) capsaicin pain + brush (brush-evoked allodynia). Capsaicin was injected intradermally on the nondominant forearm and the subjects rated pain intensity and unpleasantness on 100-mm visual analogue scales. Results: Pain intensity and unpleasantness were significantly higher during brush-evoked allodynia (74 ± 4 and 67 ± 4 mm) compared with capsaicin pain alone (60 ± 4 and 51 ± 5 mm). Brush-evoked allodynia, but not capsaicin pain alone, increased blood flow significantly in the contralateral right sensory association cortex Brodmann area (BA) 5/7, and in bilateral prefrontal cortex BA 9/10/47 and insula. No significant activity was seen in thalamus or primary somatosensory cortex (SI). Direct comparison between capsaicin pain and brush-evoked allodynia revealed significant increase in contralateral BA 5/7 only. Conclusions: The specific activation of contralateral BA 5/7 indicates that this brain region is important to the processing of brush-evoked allodynia. The involvement of BA 5/7 in brush-evoked allodynia is claimed to reflect multisensory input to this region, its role in conscious pain perception, and its neuroplastic properties.

Original languageEnglish (US)
Pages (from-to)1817-1824
Number of pages8
JournalNeurology
Volume57
Issue number10
StatePublished - Nov 27 2001
Externally publishedYes

Fingerprint

Parietal Lobe
Hyperalgesia
Capsaicin
Pain
Pain Perception
Somatosensory Cortex
Brain
Neuralgia
Prefrontal Cortex
Thalamus
Visual Analog Scale
Forearm
Positron-Emission Tomography
Volunteers

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Witting, N., Kupers, R. C., Svensson, P., Arendt-Nielsen, O. L., Gjedde, A., & Jensen, T. S. (2001). Experimental brush-evoked allodynia activates posterior parietal cortex. Neurology, 57(10), 1817-1824.

Experimental brush-evoked allodynia activates posterior parietal cortex. / Witting, Nanna; Kupers, R. C.; Svensson, P.; Arendt-Nielsen, Odont L.; Gjedde, A.; Jensen, T. S.

In: Neurology, Vol. 57, No. 10, 27.11.2001, p. 1817-1824.

Research output: Contribution to journalArticle

Witting, N, Kupers, RC, Svensson, P, Arendt-Nielsen, OL, Gjedde, A & Jensen, TS 2001, 'Experimental brush-evoked allodynia activates posterior parietal cortex', Neurology, vol. 57, no. 10, pp. 1817-1824.
Witting N, Kupers RC, Svensson P, Arendt-Nielsen OL, Gjedde A, Jensen TS. Experimental brush-evoked allodynia activates posterior parietal cortex. Neurology. 2001 Nov 27;57(10):1817-1824.
Witting, Nanna ; Kupers, R. C. ; Svensson, P. ; Arendt-Nielsen, Odont L. ; Gjedde, A. ; Jensen, T. S. / Experimental brush-evoked allodynia activates posterior parietal cortex. In: Neurology. 2001 ; Vol. 57, No. 10. pp. 1817-1824.
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AU - Witting, Nanna

AU - Kupers, R. C.

AU - Svensson, P.

AU - Arendt-Nielsen, Odont L.

AU - Gjedde, A.

AU - Jensen, T. S.

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N2 - Objective: To study the brain activation pattern of coexisting experimental ongoing pain and brush-evoked allodynia (pain evoked by innocuous brush) with the use of PET. Background: Neuropathic pain usually has two essential phenomena: ongoing pain and brush-evoked allodynia, which coexist and may influence each other. Capsaicin induces both ongoing pain and brush-evoked allodynia. Methods: Eight healthy right-handed volunteers participated in eight H215O PET scans with two blocks of four randomized conditions: 1) rest, 2) brush, 3) capsaicin pain, and 4) capsaicin pain + brush (brush-evoked allodynia). Capsaicin was injected intradermally on the nondominant forearm and the subjects rated pain intensity and unpleasantness on 100-mm visual analogue scales. Results: Pain intensity and unpleasantness were significantly higher during brush-evoked allodynia (74 ± 4 and 67 ± 4 mm) compared with capsaicin pain alone (60 ± 4 and 51 ± 5 mm). Brush-evoked allodynia, but not capsaicin pain alone, increased blood flow significantly in the contralateral right sensory association cortex Brodmann area (BA) 5/7, and in bilateral prefrontal cortex BA 9/10/47 and insula. No significant activity was seen in thalamus or primary somatosensory cortex (SI). Direct comparison between capsaicin pain and brush-evoked allodynia revealed significant increase in contralateral BA 5/7 only. Conclusions: The specific activation of contralateral BA 5/7 indicates that this brain region is important to the processing of brush-evoked allodynia. The involvement of BA 5/7 in brush-evoked allodynia is claimed to reflect multisensory input to this region, its role in conscious pain perception, and its neuroplastic properties.

AB - Objective: To study the brain activation pattern of coexisting experimental ongoing pain and brush-evoked allodynia (pain evoked by innocuous brush) with the use of PET. Background: Neuropathic pain usually has two essential phenomena: ongoing pain and brush-evoked allodynia, which coexist and may influence each other. Capsaicin induces both ongoing pain and brush-evoked allodynia. Methods: Eight healthy right-handed volunteers participated in eight H215O PET scans with two blocks of four randomized conditions: 1) rest, 2) brush, 3) capsaicin pain, and 4) capsaicin pain + brush (brush-evoked allodynia). Capsaicin was injected intradermally on the nondominant forearm and the subjects rated pain intensity and unpleasantness on 100-mm visual analogue scales. Results: Pain intensity and unpleasantness were significantly higher during brush-evoked allodynia (74 ± 4 and 67 ± 4 mm) compared with capsaicin pain alone (60 ± 4 and 51 ± 5 mm). Brush-evoked allodynia, but not capsaicin pain alone, increased blood flow significantly in the contralateral right sensory association cortex Brodmann area (BA) 5/7, and in bilateral prefrontal cortex BA 9/10/47 and insula. No significant activity was seen in thalamus or primary somatosensory cortex (SI). Direct comparison between capsaicin pain and brush-evoked allodynia revealed significant increase in contralateral BA 5/7 only. Conclusions: The specific activation of contralateral BA 5/7 indicates that this brain region is important to the processing of brush-evoked allodynia. The involvement of BA 5/7 in brush-evoked allodynia is claimed to reflect multisensory input to this region, its role in conscious pain perception, and its neuroplastic properties.

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