Experimental approaches to the study of HIV-1 latency

Yefei Han, Megan Wind-Rotolo, Hung Chih Yang, Janet D. Siliciano, Robert F. Siliciano

Research output: Contribution to journalReview articlepeer-review

Abstract

Viral latency is a reversibly non-productive state of infection that allows some viruses to evade host immune responses. As a consequence of its tropism for activated CD4+ T cells, HIV-1 can establish latent infection in resting memory CD4+ T cells, which are generated when activated CD4+ T cells return to a quiescent state. Latent HIV-1 persists as a stably integrated but transcriptionally silent provirus. In this state, the virus is unaffected by immune responses or antiretroviral drugs, and this latent reservoir in resting CD4+ T cells is a major barrier to curing the infection. Unfortunately, there is no simple assay to measure the number of latently infected cells in a patient, nor is there an entirely representative in vitro model in which to explore the molecular mechanisms of latency. This Review will consider current approaches to the analysis of HIV-1 latency both in vivo and in vitro.

Original languageEnglish (US)
Pages (from-to)95-106
Number of pages12
JournalNature Reviews Microbiology
Volume5
Issue number2
DOIs
StatePublished - Feb 1 2007

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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