Experimental allergic optic neuritis in guinea pigs: preliminary report

N. A. Rao, M. O M Tso, L. E. Zimmerman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

An experimental model for acute allergic optic neuritis was produced in adult strain 13 guinea pigs by sensitization with isogenic spinal cord emulsion in complete Freund's adjuvant. These animals exhibited 2 distinct clinical patterns: 'retrobulbar optic neuritis', with a diminished pupillary response to light despite a normal fundus, and 'neuroretinitis', with a diminished pupillary response associated with hyperemia and swelling of the disk and juxtapapillary retinal edema. Histopathologic study of those animals with 'retrobulbar neuritis' revealed that some had no abnormalities in the optic nerve or chiasm, but showed foci of mononuclear cell infiltration in the brain. Others had a mononuclear cell infiltration localized to the retrobulbar portion of the optic nerve and chiasm with multiple foci of axial and periaxial demyelination. Similar pathologic changes were present in the animals with 'neuroretinitis', but the lesions were located just behind the lamina scleralis. These animals also exhibited marked swelling of the axons at the lamina retinalis. On examination by light microscopy, the alterations in the region of optic nerve head appeared characteristic of papilledema.

Original languageEnglish (US)
Title of host publicationINVEST.OPHTHAL.VISUAL SCI.
Pages338-342
Number of pages5
Volume16
Edition4
StatePublished - 1977
Externally publishedYes

Fingerprint

Experimental Autoimmune Neuritis
Optic Neuritis
Guinea Pigs
Optic Chiasm
Retinitis
Papilledema
Optic Nerve
Light
Freund's Adjuvant
Optic Disk
Hyperemia
Demyelinating Diseases
Emulsions
Axons
Microscopy
Spinal Cord
Theoretical Models
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rao, N. A., Tso, M. O. M., & Zimmerman, L. E. (1977). Experimental allergic optic neuritis in guinea pigs: preliminary report. In INVEST.OPHTHAL.VISUAL SCI. (4 ed., Vol. 16, pp. 338-342)

Experimental allergic optic neuritis in guinea pigs : preliminary report. / Rao, N. A.; Tso, M. O M; Zimmerman, L. E.

INVEST.OPHTHAL.VISUAL SCI.. Vol. 16 4. ed. 1977. p. 338-342.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rao, NA, Tso, MOM & Zimmerman, LE 1977, Experimental allergic optic neuritis in guinea pigs: preliminary report. in INVEST.OPHTHAL.VISUAL SCI.. 4 edn, vol. 16, pp. 338-342.
Rao NA, Tso MOM, Zimmerman LE. Experimental allergic optic neuritis in guinea pigs: preliminary report. In INVEST.OPHTHAL.VISUAL SCI.. 4 ed. Vol. 16. 1977. p. 338-342
Rao, N. A. ; Tso, M. O M ; Zimmerman, L. E. / Experimental allergic optic neuritis in guinea pigs : preliminary report. INVEST.OPHTHAL.VISUAL SCI.. Vol. 16 4. ed. 1977. pp. 338-342
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