TY - JOUR
T1 - Experimental Aerobic-Anaerobic Thoracic Empyema in the Guinea Pig
AU - Mavroudis, Constantine
AU - Ganzel, Brian L.
AU - Cox, Sara K.
AU - Polk, Hiram C.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - The clinical and pathological features of experimental aerobic-anaerobic thoracic empyema in the Duncan-Harley guinea pig are described. Thoracic empyema development and early death (< 14 days after bacterial inoculation) were noted after various concentrations and species were inoculated into the pleural space with a piece of umbilical tape, which was used as a cofactor. The effect of concomitant hemothorax was also tested. Gram-negative infection was found to have a more virulent course than Gram-positive infection in the thoracic cavity. Moreover, these findings support the thesis that intrathoracic inoculation of anaerobic bacteria, even in combination with other anaerobic species, fails to produce clinical empyemas. However, anaerobic bacteria appear to enhance synergistically the virulence of sublethal and sub-empyema-forming concentrations of aerobic bacteria such as Staphylococcus aureus and Escherichia coli.
AB - The clinical and pathological features of experimental aerobic-anaerobic thoracic empyema in the Duncan-Harley guinea pig are described. Thoracic empyema development and early death (< 14 days after bacterial inoculation) were noted after various concentrations and species were inoculated into the pleural space with a piece of umbilical tape, which was used as a cofactor. The effect of concomitant hemothorax was also tested. Gram-negative infection was found to have a more virulent course than Gram-positive infection in the thoracic cavity. Moreover, these findings support the thesis that intrathoracic inoculation of anaerobic bacteria, even in combination with other anaerobic species, fails to produce clinical empyemas. However, anaerobic bacteria appear to enhance synergistically the virulence of sublethal and sub-empyema-forming concentrations of aerobic bacteria such as Staphylococcus aureus and Escherichia coli.
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U2 - 10.1016/S0003-4975(10)60618-2
DO - 10.1016/S0003-4975(10)60618-2
M3 - Article
C2 - 3548615
AN - SCOPUS:0023093101
SN - 0003-4975
VL - 43
SP - 298
EP - 302
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 3
ER -